Publications
Su Y, Xu J, Zhu Z, Chin J, Xu L, Yu H, Nudell V, Dash B, Moya EA, Ye L, Nimmerjahn A, Sun X. Brainstem Dbh+ neurons control allergen-induced airway hyperreactivity. Nature. 2024 Jul;631(8021):601-609. doi: 10.1038/s41586-024-07608-5. Epub 2024 Jul 10. PMID: 38987587; PMCID: PMC11254774.
Deng J, Labarta-Bajo L, Brandebura AN, Kahn SB, Pinto AFM, Diedrich JK, Allen NJ. Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits. bioRxiv [Preprint]. 2024 Jun 24:2024.06.19.599752. doi: 10.1101/2024.06.19.599752. PMID: 38979341; PMCID: PMC11230279.
Labarta-Bajo L, Deng J, Contreras M, Allen NJ. Protocol for the purification and transcriptomic analysis of mouse astrocytes using GFAT. STAR Protoc. 2023 Dec 15;4(4):102599. doi: 10.1016/j.xpro.2023.102599. Epub 2023 Sep 23. PMID: 37742178; PMCID: PMC10522990.
Brandebura AN, Asbell QN, Micael MKB, Allen NJ. Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down Syndrome. bioRxiv [Preprint]. 2023 Nov 28:2023.09.26.559633. doi: 10.1101/2023.09.26.559633. PMID: 37808668; PMCID: PMC10557700.
Globig AM, Zhao S, Roginsky J, Maltez VI, Guiza J, Avina-Ochoa N, Heeg M, Araujo Hoffmann F, Chaudhary O, Wang J, Senturk G, Chen D, O'Connor C, Pfaff S, Germain RN, Schalper KA, Emu B, Kaech SM. The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion. Nature. 2023 Oct;622(7982):383-392. doi: 10.1038/s41586-023-06568-6. Epub 2023 Sep 20. PMID: 37731001; PMCID: PMC10871066.
Chen D, Varanasi SK, Hara T, Traina K, Sun M, McDonald B, Farsakoglu Y, Clanton J, Xu S, Garcia-Rivera L, Mann TH, Du V, Chung HK, Xu Z, Tripple V, Casillas E, Ma S, O'Connor C, Yang Q, Zheng Y, Hunter T, Lemke G, Kaech SM. CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma. Immunity. 2023 Sep 12;56(9):2086-2104.e8. doi: 10.1016/j.immuni.2023.07.015. Epub 2023 Aug 11. PMID: 37572655.
Schafer ST, Mansour AA, Schlachetzki JCM, Pena M, Ghassemzadeh S, Mitchell L, Mar A, Quang D, Stumpf S, Ortiz IS, Lana AJ, Baek C, Zaghal R, Glass CK, Nimmerjahn A, Gage FH. An in vivo neuroimmune organoid model to study human microglia phenotypes. Cell. 2023 May 11;186(10):2111-2126.e20. doi: 10.1016/j.cell.2023.04.022. PMID: 37172564; PMCID: PMC10284271.
Brandebura AN, Paumier A, Onur TS, Allen NJ. Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders. Nat Rev Neurosci. 2023 Jan;24(1):23-39. doi: 10.1038/s41583-022-00641-1. Epub 2022 Oct 31. PMID: 36316501; PMCID: PMC10198620.
Caldwell ALM, Sancho L, Deng J, Bosworth A, Miglietta A, Diedrich JK, Shokhirev MN, Allen NJ. Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders. Nat Neurosci. 2022 Sep;25(9):1163-1178. doi: 10.1038/s41593-022-01150-1. Epub 2022 Aug 30. PMID: 36042312; PMCID: PMC10395413.
Oliinyk OS, Baloban M, Clark CL, Carey E, Pletnev S, Nimmerjahn A, Verkhusha VV. Single-domain near-infrared protein provides a scaffold for antigen-dependent fluorescent nanobodies. Nat Methods. 2022 Jun;19(6):740-750. doi: 10.1038/s41592-022-01467-6. Epub 2022 May 23. PMID: 35606446; PMCID: PMC9189029.
Farhy-Tselnicker I, Boisvert MM, Liu H, Dowling C, Erikson GA, Blanco-Suarez E, Farhy C, Shokhirev MN, Ecker JR, Allen NJ. Activity-dependent modulation of synapse-regulating genes in astrocytes. Elife. 2021 Sep 8;10:e70514. doi: 10.7554/eLife.70514. PMID: 34494546; PMCID: PMC8497060.
Huang Y, Happonen KE, Burrola PG, O'Connor C, Hah N, Huang L, Nimmerjahn A, Lemke G. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021 May;22(5):586-594. doi: 10.1038/s41590-021-00913-5. Epub 2021 Apr 15. PMID: 33859405; PMCID: PMC8102389.
Salas IH, Burgado J, Allen NJ. Glia: victims or villains of the aging brain? Neurobiol Dis. 2020 Sep;143:105008. doi: 10.1016/j.nbd.2020.105008. Epub 2020 Jul 3. PMID: 32622920.
Allen NJ, Lyons DA. Glia as architects of central nervous system formation and function. Science. 2018 Oct 12;362(6411):181-185. doi: 10.1126/science.aat0473. PMID: 30309945; PMCID: PMC6292669.
Boisvert MM, Erikson GA, Shokhirev MN, Allen NJ. The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain. Cell Rep. 2018 Jan 2;22(1):269-285. doi: 10.1016/j.celrep.2017.12.039. PMID: 29298427; PMCID: PMC5783200.
Tufail Y, Cook D, Fourgeaud L, Powers CJ, Merten K, Clark CL, Hoffman E, Ngo A, Sekiguchi KJ, O'Shea CC, Lemke G, Nimmerjahn A. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. Neuron. 2017 Feb 8;93(3):574-586.e8. doi: 10.1016/j.neuron.2016.12.021. Epub 2017 Jan 19. PMID: 28111081; PMCID: PMC5600182.
Fourgeaud L, Través PG, Tufail Y, Leal-Bailey H, Lew ED, Burrola PG, Callaway P, Zagórska A, Rothlin CV, Nimmerjahn A, Lemke G. TAM receptors regulate multiple features of microglial physiology. Nature. 2016 Apr 14;532(7598):240-244. doi: 10.1038/nature17630. Epub 2016 Apr 6. PMID: 27049947; PMCID: PMC5358512.
Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 2005 May 27;308(5726):1314-8. doi: 10.1126/science.1110647. Epub 2005 Apr 14. PMID: 15831717.