LA JOLLA–Pain typically has a clear cause–but not always. When a person touches something hot or bumps into a sharp object, it’s no surprise that it hurts. But for people with certain chronic pain disorders, including fibromyalgia and phantom limb pain, a gentle caress can result in agony.
LA JOLLA–These days, with the abundance of artificial light, TV, tablets and smartphones, adults and children alike are burning the midnight oil. What they are not burning is calories: with later bedtimes comes the tendency to eat.
LA JOLLA–Taking a single snapshot of all the bacteria that live in a mouse’s–or person’s–stomach and intestines can capture the health of the organism’s digestive system and even their risk of developing immune diseases and cancers. But it might take more than one snapshot to get a full picture, Salk researchers have discovered.
Janelle Ayres, Salk assistant professor in the Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, has been selected to receive the prestigious Ray Thomas Edwards Foundation Career Development Award. Only one three-year grant is conferred annually, aiming to foster the development of a promising early career biomedical researcher in San Diego County and to help him or her make the transition to becoming an independent investigator.
LA JOLLA–For decades, researchers have struggled to translate basic scientific discoveries about cancer into therapeutics that effectively–and with minimal side effects–shrink a tumor.
LA JOLLA–Scientists at the Salk Institute have discovered a powerful one-two punch for countering a common genetic mutation that often leads to drug-resistant cancers. The dual-drug therapy–with analogs already in use for other diseases–doubled the survival rate of mice with lung cancer and halted cancer in pancreatic cells.
LA JOLLA–Researchers at the Salk Institute have healed injured hearts of living mice by reactivating long dormant molecular machinery found in the animals’ cells, a finding that could help pave the way to new therapies for heart disorders in humans.
LA JOLLA–Like a slumbering dragon, HIV can lay dormant in a person’s cells for years, evading medical treatments only to wake up and strike at a later time, quickly replicating itself and destroying the immune system.
LA JOLLA–Like a colony of bacteria or species of animals, cancer cells within a tumor must evolve to survive. A dose of chemotherapy may kill hundreds of thousands of cancer cells, for example, but a single cell with a unique mutation can survive and quickly generate a new batch of drug-resistant cells, making cancer hard to combat.
LA JOLLA–Scientists at the Salk Institute and Beth Israel Deaconess Medical Center (BIDMC) in Boston have discovered a new class of molecules–produced in human and mouse fat–that protects against diabetes.
LA JOLLA–Scientists at the Salk Institute have scored a rare hat trick with a third assistant professor from the Waitt Advanced Biophotonics Center being named a recipient of the prestigious National Institutes of Health (NIH) Director’s New Innovator Award.
LA JOLLA—Joseph Ecker, a Salk professor and Howard Hughes Medical Institute investigator, and Margarita Behrens, Salk staff scientist, have been named recipients in the 2014 round of grants from the National Institutes of Health (NIH) through the BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative for leading-edge work in neuroscience. The grant, announced September 30, provides more than $3 million in funding to the Salk scientists over three years.
LA JOLLA–A synthetic derivative of vitamin D was found by Salk Institute researchers to collapse the barrier of cells shielding pancreatic tumors, making this seemingly impenetrable cancer much more susceptible to therapeutic drugs.
LA JOLLA–Scientists at the Salk Institute have discovered an on-and-off “switch” in cells that may hold the key to healthy aging. This switch points to a way to encourage healthy cells to keep dividing and generating, for example, new lung or liver tissue, even in old age.
LA JOLLA—For the first time, scientists have turned human skin cells into transplantable white blood cells, soldiers of the immune system that fight infections and invaders. The work, done at the Salk Institute, could let researchers create therapies that introduce into the body new white blood cells capable of attacking diseased or cancerous cells or augmenting immune responses against other disorders.
LA JOLLA–Charles Stevens, a professor in the Salk Institute’s Molecular Neurobiology Laboratory, will receive one of 36 Early Concept Grants for Exploratory Research (EAGER) from the National Science Foundation to further research on how complex behaviors emerge from the activity of the brain.
LA JOLLA—The Salk Institute for Biological Studies celebrates another successful year of fundraising with nearly $68 million raised in fiscal year 2014 to support The Campaign for Salk, the Institute’s first-ever capital fundraising campaign.
LA JOLLA–When faced with pathogens, the immune system summons a swarm of cells made up of soldiers and peacekeepers. The peacekeeping cells tell the soldier cells to halt fighting when invaders are cleared. Without this cease-fire signal, the soldiers, known as killer T cells, continue their frenzied attack and turn on the body, causing inflammation and autoimmune disorders such as allergies, asthma, rheumatoid arthritis, multiple sclerosis and type 1 diabetes.
LA JOLLA–Scientists at the Salk Institute for Biological Studies have identified a gene that regulates sleep and wake rhythms.
