Clodagh O’Shea, PhD

Professor

Molecular and Cell Biology Laboratory

Howard Hughes Medical Institute Faculty Scholar

Wicklow Chair

Salk Institute for Biological Studies - Publications

all Publications


Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J., Zhong, S. Corrigendum: The 4D nucleome project. (2017) Nature. DOI: 10.1038/nature24667

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Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J., Zhong, S., 4D Nucleome Network The 4D nucleome project. (2017) Nature. 549(7671):219-226. DOI: 10.1038/nature23884

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Ou, H.D., Phan, S., Deerinck, T.J., Thor, A., Ellisman, M.H., O'Shea, C.C. ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells. (2017) Science. 357(6349). DOI: 10.1126/science.aag0025

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Tufail, Y., Cook, D., Fourgeaud, L., Powers, C.J., Merten, K., Clark, C.L., Hoffman, E., Ngo, A., Sekiguchi, K.J., O'Shea, C.C., Lemke, G., Nimmerjahn, A. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. (2017) Neuron. 93(3):574-586.e8. DOI: 10.1016/j.neuron.2016.12.021

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Ou, H.D., Deerinck, T.J., Bushong, E., Ellisman, M.H., O'Shea, C.C. Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy. (2015) Methods. 90:39-48. DOI: 10.1016/j.ymeth.2015.06.002

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Higginbotham, J.M., O'Shea, C.C. Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains. (2015) Journal of Virology. 89(20):10260-72. DOI: 10.1128/JVI.01091-15

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Shah, G.A., O'Shea, C.C. Viral and Cellular Genomes Activate Distinct DNA Damage Responses. (2015) Cell. 162(5):987-1002. DOI: 10.1016/j.cell.2015.07.058

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Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A.C., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C.E., Lillemeier, B.F., Kemphues, K., Yates, J.R., O'Shea, C.C., Hunter, T., Dillin, A. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. (2015) Cell Metabolism. 22(1):151-63. DOI: 10.1016/j.cmet.2015.06.002

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Miyake-Stoner, S.J., O'Shea, C.C. Metabolism goes viral. (2014) Cell Metabolism. 19(4):549-50. DOI: 10.1016/j.cmet.2014.03.022

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Ou, H.D., Kwiatkowski, W., Deerinck, T.J., Noske, A., Blain, K.Y., Land, H.S., Soria, C., Powers, C.J., May, A.P., Shu, X., Tsien, R.Y., Fitzpatrick, J.A., Long, J.A., Ellisman, M.H., Choe, S., O'Shea, C.C. A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. (2012) Cell. 151(2):304-19. DOI: 10.1016/j.cell.2012.08.035

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Ou, H.D., May, A.P., O'Shea, C.C. The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication. (2011) Wiley Interdisciplinary Reviews. Systems biology and Medicine. 3(1):48-73. DOI: 10.1002/wsbm.88

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Espantman, K.C., O'Shea, C.C. aMAGEing new players enter the RING to promote ubiquitylation. (2010) Molecular Cell. 39(6):835-7. DOI: 10.1016/j.molcel.2010.09.006

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Soria, C., Estermann, F.E., Espantman, K.C., O'Shea, C.C. Heterochromatin silencing of p53 target genes by a small viral protein. (2010) Nature. 466(7310):1076-81. DOI: 10.1038/nature09307

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Iacovides, D.C., OShea, C.C., Oses-Prieto, J., Burlingame, A., McCormick, F. Critical role for arginine methylation in adenovirus-infected cells. (2007) Journal of Virology. 81(23):13209-17. DOI: 10.1128/JVI.01415-06

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Ringshausen, I., O'Shea, C.C., Finch, A.J., Swigart, L.B., Evan, G.I. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. (2006) Cancer Cell. 10(6):501-14. DOI: 10.1016/j.ccr.2006.10.010

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O'Shea, C.C. Viruses - seeking and destroying the tumor program. (2005) Oncogene. 24(52):7640-55. DOI: 10.1038/sj.onc.1209047

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O'Shea, C.C. Viruses: tools for tumor target discovery, and agents for oncolytic therapies - an introduction. (2005) Oncogene. 24(52):7636-9. DOI: 10.1038/sj.onc.1209035


O'Shea, C.C., Soria, C., Bagus, B., McCormick, F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. (2005) Cancer Cell. 8(1):61-74. DOI: 10.1016/j.ccr.2005.06.009

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O'Shea, C.C., Choi, S., McCormick, F., Stokoe, D. Adenovirus overrides cellular checkpoints for protein translation. (2005) Cell Cycle. 4(7):883-8. DOI: 10.4161/cc.4.7.1791

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O'Shea, C., Klupsch, K., Choi, S., Bagus, B., Soria, C., Shen, J., McCormick, F., Stokoe, D. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. (2005) EMBO Journal. 24(6):1211-21. DOI: 10.1038/sj.emboj.7600597

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O'Shea, C.C., Fried, M. Modulation of the ARF-p53 pathway by the small DNA tumor viruses. (2005) Cell Cycle. 4(3):449-52. DOI: 10.4161/cc.4.3.1555

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O'Shea, C.C. DNA tumor viruses -- the spies who lyse us. (2005) Current Opinion in Genetics & Development. 15(1):18-26. DOI: 10.1016/j.gde.2004.12.010

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O'Shea, C.C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Pandey, K., Soria, C., Kunich, J., Shen, Y., Habets, G., Ginzinger, D., McCormick, F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. (2004) Cancer Cell. 6(6):611-23. DOI: 10.1016/j.ccr.2004.11.012

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O'Shea, C.C., Crompton, T., Rosewell, I.R., Hayday, A.C., Owen, M.J. Raf regulates positive selection. (1996) European Journal of Immunology. 26(10):2350-5. DOI: 10.1002/eji.1830261012

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Education

BS, Biochemistry and Microbiology, University College Cork, Ireland
PhD, Imperial College London/Imperial Cancer Research Fund, U.K.
Postdoctoral Fellow, UCSF Comprehensive Cancer Center, San Francisco, U.S.A


Awards & Honors

  • 2018 Allen Distinguished Investigator Award
  • 2016 Howard Hughes Medical Institute Faculty Scholar
  • 2014 W. M. Keck Medical Research Program Award
  • 2014 Rose Hills Fellow
  • 2011Science/NSF International Science & Visualization Challenge, People's Choice
  • 2011 Anna Fuller Award for Cancer Research
  • 2010, 2011, 2012 Kavli Frontiers Fellow, National Academy of Sciences
  • 2009 Sontag Distinguished Scientist Award
  • 2009 American Cancer Society Research Scholar Award
  • 2008 ACGT Young Investigator Award for Cancer Gene Therapy
  • 2008 Arnold and Mabel Beckman Young Investigator Award
  • 2008 William Scandling Assistant Professor, Developmental Chair
  • 2007 Emerald Foundation Scholar