Professor
Molecular and Cell Biology Laboratory
Howard Hughes Medical Institute Faculty Scholar
Wicklow Chair
Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J., Zhong, S. Corrigendum: The 4D nucleome project. (2017) Nature. DOI: 10.1038/nature24667
Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J., Zhong, S., 4D Nucleome Network The 4D nucleome project. (2017) Nature. 549(7671):219-226. DOI: 10.1038/nature23884
Ou, H.D., Phan, S., Deerinck, T.J., Thor, A., Ellisman, M.H., O'Shea, C.C. ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells. (2017) Science. 357(6349). DOI: 10.1126/science.aag0025
Tufail, Y., Cook, D., Fourgeaud, L., Powers, C.J., Merten, K., Clark, C.L., Hoffman, E., Ngo, A., Sekiguchi, K.J., O'Shea, C.C., Lemke, G., Nimmerjahn, A. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. (2017) Neuron. 93(3):574-586.e8. DOI: 10.1016/j.neuron.2016.12.021
Ou, H.D., Deerinck, T.J., Bushong, E., Ellisman, M.H., O'Shea, C.C. Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy. (2015) Methods. 90:39-48. DOI: 10.1016/j.ymeth.2015.06.002
Higginbotham, J.M., O'Shea, C.C. Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains. (2015) Journal of Virology. 89(20):10260-72. DOI: 10.1128/JVI.01091-15
Shah, G.A., O'Shea, C.C. Viral and Cellular Genomes Activate Distinct DNA Damage Responses. (2015) Cell. 162(5):987-1002. DOI: 10.1016/j.cell.2015.07.058
Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A.C., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C.E., Lillemeier, B.F., Kemphues, K., Yates, J.R., O'Shea, C.C., Hunter, T., Dillin, A. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. (2015) Cell Metabolism. 22(1):151-63. DOI: 10.1016/j.cmet.2015.06.002
Miyake-Stoner, S.J., O'Shea, C.C. Metabolism goes viral. (2014) Cell Metabolism. 19(4):549-50. DOI: 10.1016/j.cmet.2014.03.022
Ou, H.D., Kwiatkowski, W., Deerinck, T.J., Noske, A., Blain, K.Y., Land, H.S., Soria, C., Powers, C.J., May, A.P., Shu, X., Tsien, R.Y., Fitzpatrick, J.A., Long, J.A., Ellisman, M.H., Choe, S., O'Shea, C.C. A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. (2012) Cell. 151(2):304-19. DOI: 10.1016/j.cell.2012.08.035
Ou, H.D., May, A.P., O'Shea, C.C. The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication. (2011) Wiley Interdisciplinary Reviews. Systems biology and Medicine. 3(1):48-73. DOI: 10.1002/wsbm.88
Espantman, K.C., O'Shea, C.C. aMAGEing new players enter the RING to promote ubiquitylation. (2010) Molecular Cell. 39(6):835-7. DOI: 10.1016/j.molcel.2010.09.006
Soria, C., Estermann, F.E., Espantman, K.C., O'Shea, C.C. Heterochromatin silencing of p53 target genes by a small viral protein. (2010) Nature. 466(7310):1076-81. DOI: 10.1038/nature09307
Iacovides, D.C., OShea, C.C., Oses-Prieto, J., Burlingame, A., McCormick, F. Critical role for arginine methylation in adenovirus-infected cells. (2007) Journal of Virology. 81(23):13209-17. DOI: 10.1128/JVI.01415-06
Ringshausen, I., O'Shea, C.C., Finch, A.J., Swigart, L.B., Evan, G.I. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. (2006) Cancer Cell. 10(6):501-14. DOI: 10.1016/j.ccr.2006.10.010
O'Shea, C.C. Viruses - seeking and destroying the tumor program. (2005) Oncogene. 24(52):7640-55. DOI: 10.1038/sj.onc.1209047
O'Shea, C.C. Viruses: tools for tumor target discovery, and agents for oncolytic therapies - an introduction. (2005) Oncogene. 24(52):7636-9. DOI: 10.1038/sj.onc.1209035
O'Shea, C.C., Soria, C., Bagus, B., McCormick, F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. (2005) Cancer Cell. 8(1):61-74. DOI: 10.1016/j.ccr.2005.06.009
O'Shea, C.C., Choi, S., McCormick, F., Stokoe, D. Adenovirus overrides cellular checkpoints for protein translation. (2005) Cell Cycle. 4(7):883-8. DOI: 10.4161/cc.4.7.1791
O'Shea, C., Klupsch, K., Choi, S., Bagus, B., Soria, C., Shen, J., McCormick, F., Stokoe, D. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. (2005) EMBO Journal. 24(6):1211-21. DOI: 10.1038/sj.emboj.7600597
O'Shea, C.C., Fried, M. Modulation of the ARF-p53 pathway by the small DNA tumor viruses. (2005) Cell Cycle. 4(3):449-52. DOI: 10.4161/cc.4.3.1555
O'Shea, C.C. DNA tumor viruses -- the spies who lyse us. (2005) Current Opinion in Genetics & Development. 15(1):18-26. DOI: 10.1016/j.gde.2004.12.010
O'Shea, C.C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Pandey, K., Soria, C., Kunich, J., Shen, Y., Habets, G., Ginzinger, D., McCormick, F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. (2004) Cancer Cell. 6(6):611-23. DOI: 10.1016/j.ccr.2004.11.012
O'Shea, C.C., Crompton, T., Rosewell, I.R., Hayday, A.C., Owen, M.J. Raf regulates positive selection. (1996) European Journal of Immunology. 26(10):2350-5. DOI: 10.1002/eji.1830261012
BS, Biochemistry and Microbiology, University College Cork, Ireland
PhD, Imperial College London/Imperial Cancer Research Fund, U.K.
Postdoctoral Fellow, UCSF Comprehensive Cancer Center, San Francisco, U.S.A