Assistant Professor
Regulatory Biology Laboratory
Helen McLoraine Developmental Chair
Rosas, J.M., Campanale, J.P., Harwood, J.L., Li, L., Bae, R., Cheng, S., Tsou, J.M., Kaiser, K.M., Engle, D.D., Montell, D.J., Pitenis, A.A. Differential Effects of Confinement on the Dynamics of Normal and Tumor-Derived Pancreatic Ductal Organoids. (2024) ACS Appl Bio Mater. DOI: 10.1021/acsabm.4c01301
Tremblay, J.R., Ortiz, J.A., Quijano, J.C., Zook, H.N., Erdem, N., LeBon, J.M., Li, W., Jou, K., Tsark, W., Mann, J.R., Kozlowski, M., Tirrell, D.A., Esni, F., Engle, D.D., Riggs, A.D., Ku, H.T. Rare, tightly-bound, multi-cellular clusters in the pancreatic ducts of adult mice function like progenitor cells and survive and proliferate after acinar cell injury. (2024) Stem Cells. DOI: 10.1093/stmcls/sxae005
Lumibao, J.C., Okhovat, S.R., Peck, K.L., Lin, X., Lande, K., Yomtoubian, S., Ng, I., Tiriac, H., Lowy, A.M., Zou, J., Engle, D.D. The effect of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids. (2023) JCI Insight. DOI: 10.1172/jci.insight.172419
Liang, G., Oh, T.G., Hah, N., Tiriac, H., Shi, Y., Truitt, M.L., Antal, C.E., Atkins, A.R., Li, Y., Fraser, C., Ng, S., Pinto, A.F.M., Nelson, D.C., Estepa, G., Bashi, S., Banayo, E., Dai, Y., Liddle, C., Yu, R.T., Hunter, T., Engle, D.D., Han, H., Von Hoff, D.D., Downes, M., Evans, R.M. Inhibiting stromal Class I HDACs curbs pancreatic cancer progression. (2023) Nature Communications. 14(1):7791. DOI: 10.1038/s41467-023-42178-6
Antal, C.E., Oh, T.G., Aigner, S., Luo, E.C., Yee, B.A., Campos, T., Tiriac, H., Rothamel, K.L., Cheng, Z., Jiao, H., Wang, A., Hah, N., Lenkiewicz, E., Lumibao, J.C., Truitt, M.L., Estepa, G., Banayo, E., Bashi, S., Esparza, E., Munoz, R.M., Diedrich, J.K., Sodir, N.M., Mueller, J.R., Fraser, C.R., Borazanci, E., Propper, D., Von Hoff, D.D., Liddle, C., Yu, R.T., Atkins, A.R., Han, H., Lowy, A.M., Barrett, M.T., Engle, D.D., Evan, G.I., Yeo, G.W., Downes, M., Evans, R.M. A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. (2023) Nature Communications. 14(1):5195. DOI: 10.1038/s41467-023-40798-6
Lumibao, J.C., Tremblay, J.R., Hsu, J., Engle, D.D. Altered glycosylation in pancreatic cancer and beyond. (2022) Journal of Experimental Medicine. 219(6). DOI: 10.1084/jem.20211505
Dasgupta, A., Shukla, S.K., Vernucci, E., King, R.J., Abrego, J., Mulder, S.E., Mullen, N.J., Graves, G., Buettner, K., Thakur, R., Murthy, D., Attri, K.S., Wang, D., Chaika, N.V., Pacheco, C.G., Rai, I., Engle, D.D., Grandgenett, P.M., Punsoni, M., Reames, B.N., Teoh-Fitzgerald, M., Oberley-Deegan, R., Yu, F., Klute, K.A., Hollingsworth, M.A., Zimmerman, M.C., Mehla, K., Sadoshima, J., Tuveson, D.A., Singh, P.K. SIRT1-NOX4 signaling axis regulates cancer cachexia. (2020) Journal of Experimental Medicine. 217(7). DOI: 10.1084/jem.20190745
Ponz-Sarvise, M., Corbo, V., Tiriac, H., Engle, D.D., Frese, K.K., Oni, T.E., Hwang, C.I., Öhlund, D., Chio, I.I.C., Baker, L.A., Filippini, D., Wright, K., Bapiro, T.E., Huang, P.S., Smith, P.D., Yu, K.H., Jodrell, D.I., Park, Y., Tuveson, D.A. Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer. (2019) Clinical Cancer Research. DOI: 10.1158/1078-0432.CCR-19-1398
Elyada, E., Bolisetty, M., Laise, P., Flynn, W.F., Courtois, E.T., Burkhart, R.A., Teinor, J.A., Belleau, P., Biffi, G., Lucito, M.S., Sivajothi, S., Armstrong, T.D., Engle, D.D., Yu, K.H., Hao, Y., Wolfgang, C.L., Park, Y., Preall, J., Jaffee, E.M., Califano, A., Robson, P., Tuveson, D.A. Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts. (2019) Cancer Discovery. 9(8):1102-1123. DOI: 10.1158/2159-8290.CD-19-0094
Engle, D.D., Tiriac, H., Rivera, K.D., Pommier, A., Whalen, S., Oni, T.E., Alagesan, B., Lee, E.J., Yao, M.A., Lucito, M.S., Spielman, B., Da Silva, B., Schoepfer, C., Wright, K., Creighton, B., Afinowicz, L., Yu, K.H., Grützmann, R., Aust, D., Gimotty, P.A., Pollard, K.S., Hruban, R.H., Goggins, M.G., Pilarsky, C., Park, Y., Pappin, D.J., Hollingsworth, M.A., Tuveson, D.A. The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice. (2019) Science. 364(6446):1156-1162. DOI: 10.1126/science.aaw3145
Tiriac, H., Belleau, P.*, Engle, D.D.*, Plenker, D., Deschênes, A., Somerville, T.D.D., Froeling, F.E.M., Burkhart, R.A., Denroche, R.E., Jang, G.H., Miyabayashi, K., Young, C.M., Patel, H., Ma, M., LaComb, J.F., Palmaira, R.L.D., Javed, A.A., Huynh, J.C., Johnson, M., Arora, K., Robine, N., Shah, M., Sanghvi, R., Goetz, A.B., Lowder, C.Y., Martello, L., Driehuis, E., LeComte, N., Askan, G., Iacobuzio-Donahue, C.A., Clevers, H., Wood, L.D., Hruban, R.H., Thompson, E., Aguirre, A.J., Wolpin, B.M., Sasson, A., Kim, J., Wu, M., Bucobo, J.C., Allen, P., Sejpal, D.V., Nealon, W., Sullivan, J.D., Winter, J.M., Gimotty, P.A., Grem, J.L., DiMaio, D.J., Buscaglia, J.M., Grandgenett, P.M., Brody, J.R., Hollingsworth, M.A., O'Kane, G.M., Notta, F., Kim, E., Crawford, J.M., Devoe, C., Ocean, A., Wolfgang, C.L., Yu, K.H., Li, E., Vakoc, C.R., Hubert, B., Fischer, S.E., Wilson, J.M., Moffitt, R., Knox, J., Krasnitz, A., Gallinger, S., Tuveson, D.A. Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. (2018) Cancer Discovery. 8(9):1112-1129. DOI: 10.1158/2159-8290.CD-18-0349
Quaranta, V., Rainer, C., Nielsen, S.R., Raymant, M.L., Ahmed, M.S., Engle, D.D., Taylor, A., Murray, T., Campbell, F., Palmer, D.H., Tuveson, D.A., Mielgo, A., Schmid, M.C. Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. (2018) Cancer Research. 78(15):4253-4269. DOI: 10.1158/0008-5472.CAN-17-3876
Wolff, R.A.*, Wang-Gillam, A.*, Alvarez, H.*, Tiriac, H.*, Engle, D.*, Hou, S.*, Groff, A.F., San Lucas, A., Bernard, V., Allenson, K., Castillo, J., Kim, D., Mulu, F., Huang, J., Stephens, B., Wistuba, I.I., Katz, M., Varadhachary, G., Park, Y., Hicks, J., Chinnaiyan, A., Scampavia, L., Spicer, T., Gerhardinger, C., Maitra, A., Tuveson, D., Rinn, J., Lizee, G., Yee, C., Levine, A.J. Dynamic changes during the treatment of pancreatic cancer. (2018) Oncotarget. 9(19):14764-14790. DOI: 10.18632/oncotarget.24483
Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A.S., Ponz-Sarvise, M., Corbo, V., Oni, T.E., Hearn, S.A., Lee, E.J., Chio, I.I., Hwang, C.I., Tiriac, H., Baker, L.A., Engle, D.D., Feig, C., Kultti, A., Egeblad, M., Fearon, D.T., Crawford, J.M., Clevers, H., Park, Y., Tuveson, D.A. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. (2017) Journal of Experimental Medicine. 214(3):579-596. DOI: 10.1084/jem.20162024
Ireland, L., Santos, A., Ahmed, M.S., Rainer, C., Nielsen, S.R., Quaranta, V., Weyer-Czernilofsky, U., Engle, D.D., Perez-Mancera, P.A., Coupland, S.E., Taktak, A., Bogenrieder, T., Tuveson, D.A., Campbell, F., Schmid, M.C., Mielgo, A. Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors. (2016) Cancer Research. 76(23):6851-6863. DOI: 10.1158/0008-5472.CAN-16-1201
Nielsen, S.R., Quaranta, V., Linford, A., Emeagi, P., Rainer, C., Santos, A., Ireland, L., Sakai, T., Sakai, K., Kim, Y.S., Engle, D., Campbell, F., Palmer, D., Ko, J.H., Tuveson, D.A., Hirsch, E., Mielgo, A., Schmid, M.C. Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. (2016) Nature Cell Biology. 18(5):549-60. DOI: 10.1038/ncb3340
Seifert, L., Werba, G., Tiwari, S., Giao Ly, N.N., Alothman, S., Alqunaibit, D., Avanzi, A., Barilla, R., Daley, D., Greco, S.H., Torres-Hernandez, A., Pergamo, M., Ochi, A., Zambirinis, C.P., Pansari, M., Rendon, M., Tippens, D., Hundeyin, M., Mani, V.R., Hajdu, C., Engle, D., Miller, G. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. (2016) Nature. 532(7598):245-9. DOI: 10.1038/nature17403
Boj, S.F., Hwang, C.I., Baker, L.A., Engle, D.D., Tuveson, D.A., Clevers, H. Model organoids provide new research opportunities for ductal pancreatic cancer. (2016) Molecular & Cellular Oncology. 3(1):e1014757. DOI: 10.1080/23723556.2015.1014757
Zambirinis, C.P., Levie, E., Nguy, S., Avanzi, A., Barilla, R., Xu, Y., Seifert, L., Daley, D., Greco, S.H., Deutsch, M., Jonnadula, S., Torres-Hernandez, A., Tippens, D., Pushalkar, S., Eisenthal, A., Saxena, D., Ahn, J., Hajdu, C., Engle, D.D., Tuveson, D., Miller, G. TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. (2015) J. Exp. Med. 212(12):2077-94. DOI: 10.1084/jem.20142162
Roy, I., McAllister, D.M., Gorse, E., Dixon, K., Piper, C.T., Zimmerman, N.P., Getschman, A.E., Tsai, S., Engle, D.D., Evans, D.B., Volkman, B.F., Kalyanaraman, B., Dwinell, M.B. Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling. (2015) Cancer Research. 75(17):3529-42. DOI: 10.1158/0008-5472.CAN-14-2645
Boj, S.F.*, Hwang, C.I.*, Baker, L.A.*, Chio, I.I.*, Engle, D.D.*, Corbo, V.*, Jager, M.*, Ponz-Sarvise, M., Tiriac, H., Spector, M.S., Gracanin, A., Oni, T., Yu, K.H., van Boxtel, R., Huch, M., Rivera, K.D., Wilson, J.P., Feigin, M.E., Öhlund, D., Handly-Santana, A., Ardito-Abraham, C.M., Ludwig, M., Elyada, E., Alagesan, B., Biffi, G., Yordanov, G.N., Delcuze, B., Creighton, B., Wright, K., Park, Y., Morsink, F.H., Molenaar, I.Q., Borel Rinkes, I.H., Cuppen, E., Hao, Y., Jin, Y., Nijman, I.J., Iacobuzio-Donahue, C., Leach, S.D., Pappin, D.J., Hammell, M., Klimstra, D.S., Basturk, O., Hruban, R.H., Offerhaus, G.J., Vries, R.G., Clevers, H., Tuveson, D.A. Organoid models of human and mouse ductal pancreatic cancer. (2015) Cell. 160(1-2):324-38. DOI: 10.1016/j.cell.2014.12.021
Naguib, A., Bencze, G., Engle, D.D., Chio, I.I., Herzka, T., Watrud, K., Bencze, S., Tuveson, D.A., Pappin, D.J., Trotman, L.C. p53 mutations change phosphatidylinositol acyl chain composition. (2015) Cell Reports. 10(1):8-19. DOI: 10.1016/j.celrep.2014.12.010
Sherman, M.H., Yu, R.T., Engle, D.D., Ding, N., Atkins, A.R., Tiriac, H., Collisson, E.A., Connor, F., Van Dyke, T., Kozlov, S., Martin, P., Tseng, T.W., Dawson, D.W., Donahue, T.R., Masamune, A., Shimosegawa, T., Apte, M.V., Wilson, J.S., Ng, B., Lau, S.L., Gunton, J.E., Wahl, G.M., Hunter, T., Drebin, J.A., O'Dwyer, P.J., Liddle, C., Tuveson, D.A., Downes, M., Evans, R.M. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. (2014) Cell. 159(1):80-93. DOI: 10.1016/j.cell.2014.08.007
Spike, B.T.*, Engle, D.D.*, Lin, J.C., Cheung, S.K., La, J., Wahl, G.M. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. (2012) Cell Stem Cell. 10(2):183-97. DOI: 10.1016/j.stem.2011.12.018
Wang, Y.V., Leblanc, M., Fox, N., Mao, J.H., Tinkum, K.L., Krummel, K., Engle, D., Piwnica-Worms, D., Piwnica-Worms, H., Balmain, A., Kaushansky, K., Wahl, G.M. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. (2011) Genes & Development. 25(13):1426-38. DOI: 10.1101/gad.2024411
BA, Biological Sciences and Asian Studies, Northwestern University
PhD, Biological Sciences, University of California, San Diego