Chen, A., Re, R.N., Davis, T.D., Tran, K., Moriuchi, Y.W., Wu, S., La Clair, J.J., Louie, G.V., Bowman, M.E., Clarke, D.J., Mackay, C.L., Campopiano, D.J., Noel, J.P., Burkart, M.D. Visualizing the Interface of Biotin and Fatty Acid Biosynthesis through SuFEx Probes. (2024) Journal of the American Chemical Society. DOI: 10.1021/jacs.3c10181

Aiyer, S., Baldwin, P.R., Tan, S.M., Shan, Z., Oh, J., Mehrani, A., Bowman, M.E., Louie, G., Passos, D.O., Đorđević-Marquardt, S., Mietzsch, M., Hull, J.A., Hoshika, S., Barad, B.A., Grotjahn, D.A., McKenna, R., Agbandje-McKenna, M., Benner, S.A., Noel, J.A.P., Wang, D., Tan, Y.Z., Lyumkis, D. Overcoming resolution attenuation during tilted cryo-EM data collection. (2024) Nature Communications. 15(1):389. DOI: 10.1038/s41467-023-44555-7

Nartey, C.M., Koo, H.J., Laurendon, C., Shaik, H.Z., O'maille, P., Noel, J.P., Morcos, F. Coevolutionary Information Captures Catalytic Functions and Reveals Divergent Roles of Terpene Synthase Interdomain Connections. (2024) Biochemistry. DOI: 10.1021/acs.biochem.3c00578

Xie, L., Bowman, M.E., Louie, G.V., Zhang, C., Ardejani, M.S., Huang, X., Chu, Q., Donaldson, C.J., Vaughan, J.M., Shan, H., Powers, E.T., Kelly, J.W., Lyumkis, D., Noel, J.P., Saghatelian, A. Biochemistry and Protein Interactions of the CYREN Microprotein. (2023) Biochemistry. DOI: 10.1021/acs.biochem.3c00397

Jiang, Z., Chen, A., Chen, J., Sekhon, A., Louie, G.V., Noel, J.P., La Clair, J.J., Burkart, M.D. Masked cerulenin enables a dual-site selective protein crosslink. (2023) Chem Sci. 14(39):10925-10933. DOI: 10.1039/d3sc02864j

Chen, A., Mindrebo, J.T., Davis, T.D., Kim, W.E., Katsuyama, Y., Jiang, Z., Ohnishi, Y., Noel, J.P., Burkart, M.D. Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states. (2022) Acta Crystallogr D Struct Biol. 78(Pt 9):1171-1179. DOI: 10.1107/S2059798322007434

Chen, P.Y., Adak, S., Chekan, J.R., Liscombe, D.K., Miyanaga, A., Bernhardt, P., Diethelm, S., Fielding, E.N., George, J.H., Miles, Z.D., Murray, L.A.M., Steele, T.S., Winter, J.M., Noel, J.P., Moore, B.S. Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis. (2022) Biochemistry. DOI: 10.1021/acs.biochem.2c00338

Aiyer, S., Strutzenberg, T.S., Bowman, M.E., Noel, J.P., Lyumkis, D. Single-Particle Cryo-EM Data Collection with Stage Tilt using Leginon. (2022) JoVE.(185) DOI: 10.3791/64136

Mindrebo, J.T., Chen, A., Kim, W.E., Re, R.N., Davis, T.D., Noel, J.P., Burkart, M.D. Structure and mechanistic analyses of the gating mechanism of elongating ketosynthases. (2021) ACS Catal. 11(12):6787-6799. DOI: 10.1021/acscatal.1c00745

Thomas, S.T., Shin, Y., La Clair, J.J., Noel, J.P. Plant-based CO drawdown and storage as SiC. (2021) RSC Adv. 11(26):15512-15518. DOI: 10.1039/d1ra00954k

Mindrebo, J.T., Misson, L.E., Johnson, C., Noel, J.P., Burkart, M.D. Activity Mapping the Acyl Carrier Protein: Elongating Ketosynthase Interaction in Fatty Acid Biosynthesis. (2020) Biochemistry. DOI: 10.1021/acs.biochem.0c00605

Misson, L.E., Mindrebo, J.T., Davis, T.D., Patel, A., McCammon, J.A., Noel, J.P., Burkart, M.D. Interfacial plasticity facilitates high reaction rate of FAS malonyl-CoA:ACP transacylase, FabD. (2020) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.2009805117

Chekan, J.R., McKinnie, S.M.K., Noel, J.P., Moore, B.S. Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an -prenyltransferase. (2020) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.2001325117

Mindrebo, J.T., Patel, A., Kim, W.E., Davis, T.D., Chen, A., Bartholow, T.G., La Clair, J.J., McCammon, J.A., Noel, J.P., Burkart, M.D. Gating mechanism of elongating β-ketoacyl-ACP synthases. (2020) Nature Communications. 11(1):1727. DOI: 10.1038/s41467-020-15455-x

Lynch, J.H., Qian, Y., Guo, L., Maoz, I., Huang, X.Q., Garcia, A.S., Louie, G., Bowman, M.E., Noel, J.P., Morgan, J.A., Dudareva, N. Modulation of auxin formation by the cytosolic phenylalanine biosynthetic pathway. (2020) Nature Chemical Biology. DOI: 10.1038/s41589-020-0519-8

Vickery, C.R., McCulloch, I.P., Sonnenschein, E.C., Beld, J., Noel, J.P., Burkart, M.D. Dissecting modular synthases through inhibition: A complementary chemical and genetic approach. (2020) Bioorganic & Medicinal Chemistry Letters. 30(2):126820. DOI: 10.1016/j.bmcl.2019.126820

Burke, J.R., La Clair, J.J., Philippe, R.N., Pabis, A., Corbella, M., Jez, J.M., Cortina, G.A., Kaltenbach, M., Bowman, M.E., Louie, G.V., Woods, K.B., Nelson, A.T., Tawfik, D.S., Kamerlin, S.C.L., Noel, J.P. Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases (2019) ACS Catalysis. 9(9):8388−8396. DOI: https://doi.org/10.1021/acscatal.9b01926

Thomas, S.T., Louie, G.V., Lubin, J.W., Lundblad, V., Noel, J.P. Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase. (2019) ACS Chemical Biology. 14(8):1767-1779. DOI: 10.1021/acschembio.9b00322

Seto, Y., Yasui, R., Kameoka, H., Tamiru, M., Cao, M., Terauchi, R., Sakurada, A., Hirano, R., Kisugi, T., Hanada, A., Umehara, M., Seo, E., Akiyama, K., Burke, J., Takeda-Kamiya, N., Li, W., Hirano, Y., Hakoshima, T., Mashiguchi, K., Noel, J.P., Kyozuka, J., Yamaguchi, S. Strigolactone perception and deactivation by a hydrolase receptor DWARF14. (2019) Nature Communications. 10(1):191. DOI: 10.1038/s41467-018-08124-7

Henry, L.K., Thomas, S.T., Widhalm, J.R., Lynch, J.H., Davis, T.C., Kessler, S.A., Bohlmann, J., Noel, J.P., Dudareva, N. Contribution of isopentenyl phosphate to plant terpenoid metabolism. (2018) Nature Plants. DOI: 10.1038/s41477-018-0220-z

Kaltenbach, M., Burke, J.R., Dindo, M., Pabis, A., Munsberg, F.S., Rabin, A., Kamerlin, S.C.L., Noel, J.P., Tawfik, D.S. Evolution of chalcone isomerase from a noncatalytic ancestor. (2018) Nature Chemical Biology. DOI: 10.1038/s41589-018-0042-3

Vickery, C.R., Cardenas, J., Bowman, M., Burkart, M.D., Da Silva, N.A., Noel, J.P. A coupled in vitro/in vivo approach for engineering a heterologous Type III PKS to enhance polyketide biosynthesis in Saccharomyces cerevisiae. (2018) Biotechnology and Bioengineering. DOI: 10.1002/bit.26564

Stewart, C., Woods, K., Macias, G., Allan, A.C., Hellens, R.P., Noel, J.P. Molecular architectures of benzoic acid-specific type III polyketide synthases. (2017) Acta Crystallographica. Section D, Structural biology. 73(Pt 12):1007-1019. DOI: 10.1107/S2059798317016618

Kersten, R.D., Lee, S., Fujita, D., Pluskal, T., Kram, S., Smith, J.E., Iwai, T., Noel, J.P., Fujita, M., Weng, J.K. A Red Algal Bourbonane Sesquiterpene Synthase Defined by Microgram-scale NMR-coupled Crystalline Sponge XRD Analysis. (2017) Journal of the American Chemical Society. DOI: 10.1021/jacs.7b09452

Wu, C.C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Fan, W., Stockley-Noel, T.A., Bowman, M.E., Noel, J.P., Evans, R.M. Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ. (2017) Proceedings of the National Academy of Sciences of the United States of America. 114(13):E2563-E2570. DOI: 10.1073/pnas.1621513114

Mindrebo, J.T., Nartey, C.M., Seto, Y., Burkart, M.D., Noel, J.P. Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom. (2016) Current Opinion in Structural Biology. 41:233-246. DOI: 10.1016/j.sbi.2016.08.005

Levsh, O., Chiang, Y.C., Tung, C.F., Noel, J.P., Wang, Y., Weng, J.K. Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase. (2016) Biochemistry. 55(45):6314-6326. DOI: 10.1021/acs.biochem.6b00887

Weng, J.K., Ye, M., Li, B., Noel, J.P. Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity. (2016) Cell. 166(4):881-93. DOI: 10.1016/j.cell.2016.06.027

Koo, H.J., Vickery, C.R., Xu, Y., Louie, G.V., O'Maille, P.E., Bowman, M., Nartey, C.M., Burkart, M.D., Noel, J.P. Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants. (2016) Journal of Antibiotics. 69(7):524-33. DOI: 10.1038/ja.2016.68

El Gamal, A., Agarwal, V., Diethelm, S., Rahman, I., Schorn, M.A., Sneed, J.M., Louie, G.V., Whalen, K.E., Mincer, T.J., Noel, J.P., Paul, V.J., Moore, B.S. Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(14):3797-802. DOI: 10.1073/pnas.1519695113

Vickery, C.R., La Clair, J.J., Burkart, M.D., Noel, J.P. Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products. (2016) Current Opinion in Chemical Biology. 31:66-73. DOI: 10.1016/j.cbpa.2016.01.008

Zheng, Z., Guo, Y., Novák, O., Chen, W., Ljung, K., Noel, J.P., Chory, J. Local auxin metabolism regulates environment-induced hypocotyl elongation. (2016) Nature Plants. 2:16025. DOI: 10.1038/nplants.2016.25

Ma, D., Li, X., Guo, Y., Chu, J., Fang, S., Yan, C., Noel, J.P., Liu, H. Cryptochrome 1 interacts with PIF4 to regulate high temperature-mediated hypocotyl elongation in response to blue light. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(1):224-9. DOI: 10.1073/pnas.1511437113

Kersten, R.D., Diedrich, J.K., Yates, J.R., Noel, J.P. Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases. (2015) ACS Chemical Biology. 10(11):2501-11. DOI: 10.1021/acschembio.5b00539

Henry, L.K., Gutensohn, M., Thomas, S.T., Noel, J.P., Dudareva, N. Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(32):10050-5. DOI: 10.1073/pnas.1504798112

Rising, K.A., Crenshaw, C.M., Koo, H.J., Subramanian, T., Chehade, K.A., Starks, C., Allen, K.D., Andres, D.A., Spielmann, H.P., Noel, J.P., Chappell, J. Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. (2015) ACS Chemical Biology. 10(7):1729-36. DOI: 10.1021/acschembio.5b00145

Pan, H., Zhou, R., Louie, G.V., Mühlemann, J.K., Bomati, E.K., Bowman, M.E., Dudareva, N., Dixon, R.A., Noel, J.P., Wang, X. Structural studies of cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase, key enzymes of monolignol biosynthesis. (2014) Plant Cell. 26(9):3709-27. DOI: 10.1105/tpc.114.127399

Vickery, C.R., Kosa, N.M., Casavant, E.P., Duan, S., Noel, J.P., Burkart, M.D. Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of Mycobacteria. (2014) ACS Chemical Biology. 9(9):1939-44. DOI: 10.1021/cb500263p

Procko, C., Crenshaw, C.M., Ljung, K., Noel, J.P., Chory, J. Cotyledon-Generated Auxin Is Required for Shade-Induced Hypocotyl Growth in Brassica rapa. (2014) Plant Physiology. 165(3):1285-1301. DOI: 10.1104/pp.114.241844

Bomati, E.K., Haley, J.E., Noel, J.P., Deheyn, D.D. Spectral and structural comparison between bright and dim green fluorescent proteins in Amphioxus. (2014) Scientific Reports. 4:5469. DOI: 10.1038/srep05469

Hoppmann, C., Lacey, V.K., Louie, G.V., Wei, J., Noel, J.P., Wang, L. Genetically encoding photoswitchable click amino acids in Escherichia coli and mammalian cells. (2014) Angewandte Chemie. 53(15):3932-6. DOI: 10.1002/anie.201400001

Beld, J., Sonnenschein, E.C., Vickery, C.R., Noel, J.P., Burkart, M.D. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life. (2014) Natural Product Reports. 31(1):61-108. DOI: 10.1039/c3np70054b

Schorn, M., Zettler, J., Noel, J.P., Dorrestein, P.C., Moore, B.S., Kaysser, L. Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. (2014) ACS Chemical Biology. 9(1):301-9. DOI: 10.1021/cb400699p

Dellas, N., Thomas, S.T., Manning, G., Noel, J.P. Discovery of a metabolic alternative to the classical mevalonate pathway. (2013) Elife. 2:e00672. DOI: 10.7554/eLife.00672

Teufel, R., Miyanaga, A., Michaudel, Q., Stull, F., Louie, G., Noel, J.P., Baran, P.S., Palfey, B., Moore, B.S. Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. (2013) Nature. 503(7477):552-556. DOI: 10.1038/nature12643

Lacey, V.K., Louie, G.V., Noel, J.P., Wang, L. Expanding the library and substrate diversity of the pyrrolysyl-tRNA synthetase to incorporate unnatural amino acids containing conjugated rings. (2013) Chembiochem. 14(16):2100-5. DOI: 10.1002/cbic.201300400

Stewart, C., Vickery, C.R., Burkart, M.D., Noel, J.P. Confluence of structural and chemical biology: plant polyketide synthases as biocatalysts for a bio-based future. (2013) Current Opinion in Plant Biology. 16(3):365-72. DOI: 10.1016/j.pbi.2013.02.004

Weng, J.K., Noel, J.P. Chemodiversity in Selaginella: a reference system for parallel and convergent metabolic evolution in terrestrial plants. (2013) Frontiers in Plant Science. 4:119. DOI: 10.3389/fpls.2013.00119

Guo, Y., Zheng, Z., La Clair, J.J., Chory, J., Noel, J.P. Smoke-derived karrikin perception by the α/β-hydrolase KAI2 from Arabidopsis. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(20):8284-9. DOI: 10.1073/pnas.1306265110

Zheng, Z., Guo, Y., Novák, O., Dai, X., Zhao, Y., Ljung, K., Noel, J.P., Chory, J. Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1. (2013) Nature Chemical Biology. 9(4):244-6. DOI: 10.1038/nchembio.1178

Weng, J.K., Noel, J.P. The remarkable pliability and promiscuity of specialized metabolism. (2012) Cold Spring Harbor Symposia on Quantitative Biology. 77:309-20. DOI: 10.1101/sqb.2012.77.014787

Elleder, D., Baiga, T.J., Russell, R.L., Naughton, J.A., Hughes, S.H., Noel, J.P., Young, J.A. Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase. (2012) Virology Journal. 9:305. DOI: 10.1186/1743-422X-9-305

Liscombe, D.K., Louie, G.V., Noel, J.P. Architectures, mechanisms and molecular evolution of natural product methyltransferases. (2012) Natural Product Reports. 29(10):1238-50. DOI: 10.1039/c2np20029e

Zhang, M., Wang, X.J., Chen, X., Bowman, M.E., Luo, Y., Noel, J.P., Ellington, A.D., Etzkorn, F.A., Zhang, Y. Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code. (2012) ACS Chemical Biology. 7(8):1462-70. DOI: 10.1021/cb3000887

Weng, J.K., Philippe, R.N., Noel, J.P. The rise of chemodiversity in plants. (2012) Science. 336(6089):1667-70. DOI: 10.1126/science.1217411

Ngaki, M.N., Louie, G.V., Philippe, R.N., Manning, G., Pojer, F., Bowman, M.E., Li, L., Larsen, E., Wurtele, E.S., Noel, J.P. Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. (2012) Nature. 485(7399):530-3. DOI: 10.1038/nature11009

Auldridge, M.E., Guo, Y., Austin, M.B., Ramsey, J., Fridman, E., Pichersky, E., Noel, J.P. Emergent decarboxylase activity and attenuation of α/β-hydrolase activity during the evolution of methylketone biosynthesis in tomato. (2012) Plant Cell. 24(4):1596-607. DOI: 10.1105/tpc.111.093997

Weng, J.K., Noel, J.P. Structure-function analyses of plant type III polyketide synthases. (2012) Meth. Enzymol. 515:317-35. DOI: 10.1016/B978-0-12-394290-6.00014-8

Shen, B., Xiang, Z., Miller, B., Louie, G., Wang, W., Noel, J.P., Gage, F.H., Wang, L. Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. (2011) Stem Cells. 29(8):1231-40. DOI: 10.1002/stem.679

Hess, B.A., Smentek, L., Noel, J.P., O'Maille, P.E. Physical constraints on sesquiterpene diversity arising from cyclization of the eudesm-5-yl carbocation. (2011) Journal of the American Chemical Society. 133(32):12632-41. DOI: 10.1021/ja203342p

Takimoto, J.K., Dellas, N., Noel, J.P., Wang, L. Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids. (2011) ACS Chemical Biology. 6(7):733-43. DOI: 10.1021/cb200057a

Hothorn, M., Belkhadir, Y., Dreux, M., Dabi, T., Noel, J.P., Wilson, I.A., Chory, J. Structural basis of steroid hormone perception by the receptor kinase BRI1. (2011) Nature. 474(7352):467-71. DOI: 10.1038/nature10153

Louie, G.V., Bowman, M.E., Tu, Y., Mouradov, A., Spangenberg, G., Noel, J.P. Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference. (2010) Plant Cell. 22(12):4114-27. DOI: 10.1105/tpc.110.077578

Noel, J.P. Chemical biology: Synthetic metabolism goes green. (2010) Nature. 468(7322):380-1. DOI: 10.1038/468380a

Tu, Y., Rochfort, S., Liu, Z., Ran, Y., Griffith, M., Badenhorst, P., Louie, G.V., Bowman, M.E., Smith, K.F., Noel, J.P., Mouradov, A., Spangenberg, G. Functional analyses of caffeic acid O-Methyltransferase and Cinnamoyl-CoA-reductase genes from perennial ryegrass (Lolium perenne). (2010) Plant Cell. 22(10):3357-73. DOI: 10.1105/tpc.109.072827

Yu, G., Nguyen, T.T., Guo, Y., Schauvinhold, I., Auldridge, M.E., Bhuiyan, N., Ben-Israel, I., Iijima, Y., Fridman, E., Noel, J.P., Pichersky, E. Enzymatic functions of wild tomato methylketone synthases 1 and 2. (2010) Plant Physiology. 154(1):67-77. DOI: 10.1104/pp.110.157073

Dellas, N., Noel, J.P. Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates. (2010) ACS Chemical Biology. 5(6):589-601. DOI: 10.1021/cb1000313

Zhang, M., Liu, J., Kim, Y., Dixon, J.E., Pfaff, S.L., Gill, G.N., Noel, J.P., Zhang, Y. Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. (2010) Protein Science. 19(5):974-86. DOI: 10.1002/pro.375

Noel, J.P., Dellas, N., Faraldos, J.A., Zhao, M., Hess, B.A., Smentek, L., Coates, R.M., O'Maille, P.E. Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. (2010) ACS Chemical Biology. 5(4):377-92. DOI: 10.1021/cb900295g

Faraldos, J.A., O'Maille, P.E., Dellas, N., Noel, J.P., Coates, R.M. Bisabolyl-derived sesquiterpenes from tobacco 5-epi-aristolochene synthase-catalyzed cyclization of (2Z,6E)-farnesyl diphosphate. (2010) Journal of the American Chemical Society. 132(12):4281-9. DOI: 10.1021/ja909886q

Ben-Israel, I., Yu, G., Austin, M.B., Bhuiyan, N., Auldridge, M., Nguyen, T., Schauvinhold, I., Noel, J.P., Pichersky, E., Fridman, E. Multiple biochemical and morphological factors underlie the production of methylketones in tomato trichomes. (2009) Plant Physiology. 151(4):1952-64. DOI: 10.1104/pp.109.146415

Lear, M.J., Simon, O., Foley, T.L., Burkart, M.D., Baiga, T.J., Noel, J.P., DiPasquale, A.G., Rheingold, A.L., La Clair, J.J. Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. (2009) J. Nat. Prod. 72(11):1980-7. DOI: 10.1021/np9002838

Koeduka, T., Orlova, I., Baiga, T.J., Noel, J.P., Dudareva, N., Pichersky, E. The lack of floral synthesis and emission of isoeugenol in Petunia axillaris subsp. parodii is due to a mutation in the isoeugenol synthase gene. (2009) Plant Journal. 58(6):961-9. DOI: 10.1111/j.1365-313X.2009.03834.x

Koeduka, T., Baiga, T.J., Noel, J.P., Pichersky, E. Biosynthesis of t-anethole in anise: characterization of t-anol/isoeugenol synthase and an O-methyltransferase specific for a C7-C8 propenyl side chain. (2009) Plant Physiology. 149(1):384-94. DOI: 10.1104/pp.108.128066

O'Maille, P.E., Malone, A., Dellas, N., Andes Hess, B., Smentek, L., Sheehan, I., Greenhagen, B.T., Chappell, J., Manning, G., Noel, J.P. Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. (2008) Nature Chemical Biology. 4(10):617-23. DOI: 10.1038/nchembio.113

Savaldi-Goldstein, S., Baiga, T.J., Pojer, F., Dabi, T., Butterfield, C., Parry, G., Santner, A., Dharmasiri, N., Tao, Y., Estelle, M., Noel, J.P., Chory, J. New auxin analogs with growth-promoting effects in intact plants reveal a chemical strategy to improve hormone delivery. (2008) Proceedings of the National Academy of Sciences of the United States of America. 105(39):15190-5. DOI: 10.1073/pnas.0806324105

Eustáquio, A.S., Härle, J., Noel, J.P., Moore, B.S. S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. (2008) Chembiochem. 9(14):2215-9. DOI: 10.1002/cbic.200800341

Kumano, T., Richard, S.B., Noel, J.P., Nishiyama, M., Kuzuyama, T. Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities. (2008) Bioorganic & Medicinal Chemistry. 16(17):8117-26. DOI: 10.1016/j.bmc.2008.07.052

Baiga, T.J., Guo, H., Xing, Y., O'Doherty, G.A., Dillin, A., Austin, M.B., Noel, J.P., La Clair, J.J. Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx. (2008) ACS Chemical Biology. 3(5):294-304. DOI: 10.1021/cb700269e

Tello, M., Kuzuyama, T., Heide, L., Noel, J.P., Richard, S.B. The ABBA family of aromatic prenyltransferases: broadening natural product diversity. (2008) Cellular and Molecular Life Sciences. 65(10):1459-63. DOI: 10.1007/s00018-008-7579-3

Koeduka, T., Louie, G.V., Orlova, I., Kish, C.M., Ibdah, M., Wilkerson, C.G., Bowman, M.E., Baiga, T.J., Noel, J.P., Dudareva, N., Pichersky, E. The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages. (2008) Plant Journal. 54(3):362-74. DOI: 10.1111/j.1365-313X.2008.03412.x

Tao, Y., Ferrer, J.L., Ljung, K., Pojer, F., Hong, F., Long, J.A., Li, L., Moreno, J.E., Bowman, M.E., Ivans, L.J., Cheng, Y., Lim, J., Zhao, Y., Ballaré, C.L., Sandberg, G., Noel, J.P., Chory, J. Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants. (2008) Cell. 133(1):164-76. DOI: 10.1016/j.cell.2008.01.049

Austin, M.B., O'Maille, P.E., Noel, J.P. Evolving biosynthetic tangos negotiate mechanistic landscapes. (2008) Nature Chemical Biology. 4(4):217-22. DOI: 10.1038/nchembio0408-217

Ferrer, J.L., Austin, M.B., Stewart, C., Noel, J.P. Structure and function of enzymes involved in the biosynthesis of phenylpropanoids. (2008) Plant Physiology and Biochemistry. 46(3):356-70. DOI: 10.1016/j.plaphy.2007.12.009

Zhao, N., Ferrer, J.L., Ross, J., Guan, J., Yang, Y., Pichersky, E., Noel, J.P., Chen, F. Structural, biochemical, and phylogenetic analyses suggest that indole-3-acetic acid methyltransferase is an evolutionarily ancient member of the SABATH family. (2008) Plant Physiology. 146(2):455-67. DOI: 10.1104/pp.107.110049

Eustáquio, A.S., Pojer, F., Noel, J.P., Moore, B.S. Discovery and characterization of a marine bacterial SAM-dependent chlorinase. (2008) Nature Chemical Biology. 4(1):69-74. DOI: 10.1038/nchembio.2007.56

Noel, J.P. Digging for answers, smelling a hint of success and tasting triumph. (2007) Nature Chemical Biology. 3(11):690-1. DOI: 10.1038/nchembio1107-690

Louie, G.V., Baiga, T.J., Bowman, M.E., Koeduka, T., Taylor, J.H., Spassova, S.M., Pichersky, E., Noel, J.P. Structure and reaction mechanism of basil eugenol synthase. (2007) PLOS One. 2(10):e993. DOI: 10.1371/journal.pone.0000993

Faraldos, J.A., Zhao, Y., O'Maille, P.E., Noel, J.P., Coates, R.M. Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate. (2007) Chembiochem. 8(15):1826-33. DOI: 10.1002/cbic.200700398

Takahashi, S., Yeo, Y.S., Zhao, Y., O'Maille, P.E., Greenhagen, B.T., Noel, J.P., Coates, R.M., Chappell, J. Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. (2007) Journal of Biological Chemistry. 282(43):31744-54. DOI: 10.1074/jbc.M703378200

Wang, W., Takimoto, J.K., Louie, G.V., Baiga, T.J., Noel, J.P., Lee, K.F., Slesinger, P.A., Wang, L. Genetically encoding unnatural amino acids for cellular and neuronal studies. (2007) Nature Neuroscience. 10(8):1063-72. DOI: 10.1038/nn1932

Haagen, Y., Unsöld, I., Westrich, L., Gust, B., Richard, S.B., Noel, J.P., Heide, L. A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates. (2007) FEBS Letters. 581(16):2889-93. DOI: 10.1016/j.febslet.2007.05.031

Zhang, Y., Daum, S., Wildemann, D., Zhou, X.Z., Verdecia, M.A., Bowman, M.E., Lücke, C., Hunter, T., Lu, K.P., Fischer, G., Noel, J.P. Structural basis for high-affinity peptide inhibition of human Pin1. (2007) ACS Chemical Biology. 2(5):320-8. DOI: 10.1021/cb7000044

Takahashi, S., Yeo, Y., Greenhagen, B.T., McMullin, T., Song, L., Maurina-Brunker, J., Rosson, R., Noel, J.P., Chappell, J. Metabolic engineering of sesquiterpene metabolism in yeast. (2007) Biotechnology and Bioengineering. 97(1):170-81. DOI: 10.1002/bit.21216

Moffitt, M.C., Louie, G.V., Bowman, M.E., Pence, J., Noel, J.P., Moore, B.S. Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization. (2007) Biochemistry. 46(4):1004-12. DOI: 10.1021/bi061774g

Varbanova, M., Yamaguchi, S., Yang, Y., McKelvey, K., Hanada, A., Borochov, R., Yu, F., Jikumaru, Y., Ross, J., Cortes, D., Ma, C.J., Noel, J.P., Mander, L., Shulaev, V., Kamiya, Y., Rodermel, S., Weiss, D., Pichersky, E. Methylation of gibberellins by Arabidopsis GAMT1 and GAMT2. (2007) Plant Cell. 19(1):32-45. DOI: 10.1105/tpc.106.044602

Louie, G.V., Bowman, M.E., Moffitt, M.C., Baiga, T.J., Moore, B.S., Noel, J.P. Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. (2006) Chemistry & Biology. 13(12):1327-38. DOI: 10.1016/j.chembiol.2006.11.011

Liu, C.J., Deavours, B.E., Richard, S.B., Ferrer, J.L., Blount, J.W., Huhman, D., Dixon, R.A., Noel, J.P. Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. (2006) Plant Cell. 18(12):3656-69. DOI: 10.1105/tpc.106.041376

Zhang, Y., Kim, Y., Genoud, N., Gao, J., Kelly, J.W., Pfaff, S.L., Gill, G.N., Dixon, J.E., Noel, J.P. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. (2006) Molecular Cell. 24(5):759-70. DOI: 10.1016/j.molcel.2006.10.027

Ferrer, J.L., Dupuy, J., Borel, F., Jacquamet, L., Noel, J.P., Dulic, V. Structural basis for the modulation of CDK-dependent/independent activity of cyclin D1. (2006) Cell Cycle. 5(23):2760-8. DOI: 10.4161/cc.5.23.3506

Song, L., Barona-Gomez, F., Corre, C., Xiang, L., Udwary, D.W., Austin, M.B., Noel, J.P., Moore, B.S., Challis, G.L. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. (2006) Journal of the American Chemical Society. 128(46):14754-5. DOI: 10.1021/ja065247w

Deavours, B.E., Liu, C.J., Naoumkina, M.A., Tang, Y., Farag, M.A., Sumner, L.W., Noel, J.P., Dixon, R.A. Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula. (2006) Plant Molecular Biology. 62(4-5):715-33. DOI: 10.1007/s11103-006-9050-x

Austin, M.B., Saito, T., Bowman, M.E., Haydock, S., Kato, A., Moore, B.S., Kay, R.R., Noel, J.P. Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. (2006) Nature Chemical Biology. 2(9):494-502. DOI: 10.1038/nchembio811

Pojer, F., Ferrer, J.L., Richard, S.B., Nagegowda, D.A., Chye, M.L., Bach, T.J., Noel, J.P. Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(31):11491-6. DOI: 10.1073/pnas.0604935103

Jäger, M., Zhang, Y., Bieschke, J., Nguyen, H., Dendle, M., Bowman, M.E., Noel, J.P., Gruebele, M., Kelly, J.W. Structure-function-folding relationship in a WW domain. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(28):10648-53. DOI: 10.1073/pnas.0600511103

Greenhagen, B.T., O'Maille, P.E., Noel, J.P., Chappell, J. Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(26):9826-31. DOI: 10.1073/pnas.0601605103

Koeduka, T., Fridman, E., Gang, D.R., Vassão, D.G., Jackson, B.L., Kish, C.M., Orlova, I., Spassova, S.M., Lewis, N.G., Noel, J.P., Baiga, T.J., Dudareva, N., Pichersky, E. Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(26):10128-33. DOI: 10.1073/pnas.0603732103

O'Maille, P.E., Chappell, J., Noel, J.P. Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-epi-aristolochene synthase. (2006) Archives of Biochemistry and Biophysics. 448(1-2):73-82. DOI: 10.1016/j.abb.2005.10.028

Coiner, H., Schröder, G., Wehinger, E., Liu, C.J., Noel, J.P., Schwab, W., Schröder, J. Methylation of sulfhydryl groups: a new function for a family of small molecule plant O-methyltransferases. (2006) Plant Journal. 46(2):193-205. DOI: 10.1111/j.1365-313X.2006.02680.x

Schenk, D.J., Starks, C.M., Manna, K.R., Chappell, J., Noel, J.P., Coates, R.M. Stereochemistry and deuterium isotope effects associated with the cyclization-rearrangements catalyzed by tobacco epiaristolochene and hyoscyamus premnaspirodiene synthases, and the chimeric CH4 hybri (2006) Archives of Biochemistry and Biophysics. 448(1-2):31-44. DOI: 10.1016/j.abb.2005.09.002

Yang, Y., Yuan, J.S., Ross, J., Noel, J.P., Pichersky, E., Chen, F. An Arabidopsis thaliana methyltransferase capable of methylating farnesoic acid. (2006) Archives of Biochemistry and Biophysics. 448(1-2):123-32. DOI: 10.1016/j.abb.2005.08.006

Lherbet, C., Pojer, F., Richard, S.B., Noel, J.P., Poulter, C.D. Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway. (2006) Biochemistry. 45(11):3548-53. DOI: 10.1021/bi0520075

Pichersky, E., Noel, J.P., Dudareva, N. Biosynthesis of plant volatiles: nature's diversity and ingenuity. (2006) Science. 311(5762):808-11. DOI: 10.1126/science.1118510

Testa, C.A., Lherbet, C., Pojer, F., Noel, J.P., Poulter, C.D. Cloning and expression of IspDF from Mesorhizobium loti. Characterization of a bifunctional protein that catalyzes non-consecutive steps in the methylerythritol phosphate pathway. (2006) Biochimica et Biophysica Acta. 1764(1):85-96. DOI: 10.1016/j.bbapap.2005.08.006

Verdecia, M.A., Larkin, R.M., Ferrer, J.L., Riek, R., Chory, J., Noel, J.P. [Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding]. (2005) Medecine Sciences (Paris). 21(11):903-4. DOI: 10.1051/medsci/20052111903

Bomati, E.K., Austin, M.B., Bowman, M.E., Dixon, R.A., Noel, J.P. Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis. (2005) Journal of Biological Chemistry. 280(34):30496-503. DOI: 10.1074/jbc.M502239200

Kuzuyama, T., Noel, J.P., Richard, S.B. Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products. (2005) Nature. 435(7044):983-7. DOI: 10.1038/nature03668

Noel, J.P., Austin, M.B., Bomati, E.K. Structure-function relationships in plant phenylpropanoid biosynthesis. (2005) Current Opinion in Plant Biology. 8(3):249-53. DOI: 10.1016/j.pbi.2005.03.013

Effmert, U., Saschenbrecker, S., Ross, J., Negre, F., Fraser, C.M., Noel, J.P., Dudareva, N., Piechulla, B. Floral benzenoid carboxyl methyltransferases: from in vitro to in planta function. (2005) Phytochemistry. 66(11):1211-30. DOI: 10.1016/j.phytochem.2005.03.031

Verdecia, M.A., Larkin, R.M., Ferrer, J.L., Riek, R., Chory, J., Noel, J.P. Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding. (2005) PLOS Biology. 3(5):e151. DOI: 10.1371/journal.pbio.0030151

Bomati, E.K., Noel, J.P. Structural and kinetic basis for substrate selectivity in Populus tremuloides sinapyl alcohol dehydrogenase. (2005) Plant Cell. 17(5):1598-611. DOI: 10.1105/tpc.104.029983

Ferrer, J.L., Zubieta, C., Dixon, R.A., Noel, J.P. Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase. (2005) Plant Physiology. 137(3):1009-17. DOI: 10.1104/pp.104.048751

Takahashi, S., Zhao, Y., O'Maille, P.E., Greenhagen, B.T., Noel, J.P., Coates, R.M., Chappell, J. Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes. (2005) Journal of Biological Chemistry. 280(5):3686-96. DOI: 10.1074/jbc.M411870200

O'Maille, P.E., Chappell, J., Noel, J.P. A single-vial analytical and quantitative gas chromatography-mass spectrometry assay for terpene synthases. (2004) Analytical Biochemistry. 335(2):210-7. DOI: 10.1016/j.ab.2004.09.011

Austin, M.B., Izumikawa, M., Bowman, M.E., Udwary, D.W., Ferrer, J.L., Moore, B.S., Noel, J.P. Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. (2004) Journal of Biological Chemistry. 279(43):45162-74. DOI: 10.1074/jbc.M406567200

Austin, M.B., Bowman, M.E., Ferrer, J.L., Schröder, J., Noel, J.P. An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases. (2004) Chemistry & Biology. 11(9):1179-94. DOI: 10.1016/j.chembiol.2004.05.024

Richard, S.B., Lillo, A.M., Tetzlaff, C.N., Bowman, M.E., Noel, J.P., Cane, D.E. Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids. (2004) Biochemistry. 43(38):12189-97. DOI: 10.1021/bi0487241

Pott, M.B., Hippauf, F., Saschenbrecker, S., Chen, F., Ross, J., Kiefer, I., Slusarenko, A., Noel, J.P., Pichersky, E., Effmert, U., Piechulla, B. Biochemical and structural characterization of benzenoid carboxyl methyltransferases involved in floral scent production in Stephanotis floribunda and Nicotiana suaveolens. (2004) Plant Physiology. 135(4):1946-55. DOI: 10.1104/pp.104.041806

Hendricks, C.L., Ross, J.R., Pichersky, E., Noel, J.P., Zhou, Z.S. An enzyme-coupled colorimetric assay for S-adenosylmethionine-dependent methyltransferases. (2004) Analytical Biochemistry. 326(1):100-5. DOI: 10.1016/j.ab.2003.11.014

O'Maille, P.E., Tsai, M.D., Greenhagen, B.T., Chappell, J., Noel, J.P. Gene library synthesis by structure-based combinatorial protein engineering. (2004) Meth. Enzymol. 388:75-91. DOI: 10.1016/S0076-6879(04)88008-X

Chen, F., D'Auria, J.C., Tholl, D., Ross, J.R., Gershenzon, J., Noel, J.P., Pichersky, E. An Arabidopsis thaliana gene for methylsalicylate biosynthesis, identified by a biochemical genomics approach, has a role in defense. (2003) Plant Journal. 36(5):577-88.

Zubieta, C., Ross, J.R., Koscheski, P., Yang, Y., Pichersky, E., Noel, J.P. Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family. (2003) Plant Cell. 15(8):1704-16.

Izumikawa, M., Shipley, P.R., Hopke, J.N., O'Hare, T., Xiang, L., Noel, J.P., Moore, B.S. Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). (2003) Journal of Industrial Microbiology & Biotechnology. 30(8):510-5. DOI: 10.1007/s10295-003-0075-8

Sonnenburg, E.D., Bilwes, A., Hunter, T., Noel, J.P. The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. (2003) Biochemistry. 42(26):7904-14. DOI: 10.1021/bi0340503

Downes, M., Verdecia, M.A., Roecker, A.J., Hughes, R., Hogenesch, J.B., Kast-Woelbern, H.R., Bowman, M.E., Ferrer, J.L., Anisfeld, A.M., Edwards, P.A., Rosenfeld, J.M., Alvarez, J.G., Noel, J.P., Nicolaou, K.C., Evans, R.M. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. (2003) Molecular Cell. 11(4):1079-92.

Austin, M.B., Noel, J.P. The chalcone synthase superfamily of type III polyketide synthases. (2003) Natural Product Reports. 20(1):79-110.

Verdecia, M.A., Joazeiro, C.A., Wells, N.J., Ferrer, J.L., Bowman, M.E., Hunter, T., Noel, J.P. Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. (2003) Molecular Cell. 11(1):249-59.

Moore, B.S., Hertweck, C., Hopke, J.N., Izumikawa, M., Kalaitzis, J.A., Nilsen, G., O'Hare, T., Piel, J., Shipley, P.R., Xiang, L., Austin, M.B., Noel, J.P. Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone. (2002) Journal of Natural Products. 65(12):1956-62. DOI: 10.1021/np020230m

Beachy, R., Bennetzen, J.L., Chassy, B.M., Chrispeels, M., Chory, J., Ecker, J.R., Noel, J.P., Kay, S.A., Dean, C., Lamb, C., Jones, J., Santerre, C.R., Schroeder, J.I., Umen, J., Yanofsky, M., Wessler, S., Zhao, Y., Parrott, W. Divergent perspectives on GM food. (2002) Nature Biotechnology. 20(12):1195-6; author reply 1197. DOI: 10.1038/nbt1202-1195

Zubieta, C., Kota, P., Ferrer, J.L., Dixon, R.A., Noel, J.P. Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase. (2002) Plant Cell. 14(6):1265-77.

Jez, J.M., Bowman, M.E., Noel, J.P. Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. (2002) Proceedings of the National Academy of Sciences of the United States of America. 99(8):5319-24. DOI: 10.1073/pnas.082590499

Jez, J.M., Bowman, M.E., Noel, J.P. Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. (2002) Biochemistry. 41(16):5168-76.

Richard, S.B., Ferrer, J.L., Bowman, M.E., Lillo, A.M., Tetzlaff, C.N., Cane, D.E., Noel, J.P. Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. (2002) Journal of Biological Chemistry. 277(10):8667-72. DOI: 10.1074/jbc.C100739200

Gang, D.R., Lavid, N., Zubieta, C., Chen, F., Beuerle, T., Lewinsohn, E., Noel, J.P., Pichersky, E. Characterization of phenylpropene O-methyltransferases from sweet basil: facile change of substrate specificity and convergent evolution within a plant O-methyltransferase family. (2002) Plant Cell. 14(2):505-19.

Jez, J.M., Noel, J.P. Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences. (2002) Journal of Biological Chemistry. 277(2):1361-9. DOI: 10.1074/jbc.M109224200

Lu, P.J., Zhou, X.Z., Liou, Y.C., Noel, J.P., Lu, K.P. Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. (2002) Journal of Biological Chemistry. 277(4):2381-4. DOI: 10.1074/jbc.C100228200

Jez, J.M., Ferrer, J.L., Bowman, M.E., Austin, M.B., Schröder, J., Dixon, R.A., Noel, J.P. Structure and mechanism of chalcone synthase-like polyketide synthases. (2001) Journal of Industrial Microbiology & Biotechnology. 27(6):393-8. DOI: 10.1038/sj/jim/7000188

Jez, J.M., Bowman, M.E., Noel, J.P. Structure-guided programming of polyketide chain-length determination in chalcone synthase. (2001) Biochemistry. 40(49):14829-38.

Richard, S.B., Bowman, M.E., Kwiatkowski, W., Kang, I., Chow, C., Lillo, A.M., Cane, D.E., Noel, J.P. Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis. (2001) Nature Structural Biology. 8(7):641-8. DOI: 10.1038/89691

Zubieta, C., He, X.Z., Dixon, R.A., Noel, J.P. Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases. (2001) Nature Structural Biology. 8(3):271-9. DOI: 10.1038/85029

Jez, J.M., Austin, M.B., Ferrer, J., Bowman, M.E., Schröder, J., Noel, J.P. Structural control of polyketide formation in plant-specific polyketide synthases. (2000) Chemistry & Biology. 7(12):919-30.

Jez, J.M., Noel, J.P. Mechanism of chalcone synthase. pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase. (2000) Journal of Biological Chemistry. 275(50):39640-6. DOI: 10.1074/jbc.M008569200

Jez, J.M., Bowman, M.E., Dixon, R.A., Noel, J.P. Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. (2000) Nature Structural Biology. 7(9):786-91. DOI: 10.1038/79025

Verdecia, M.A., Bowman, M.E., Lu, K.P., Hunter, T., Noel, J.P. Structural basis for phosphoserine-proline recognition by group IV WW domains. (2000) Nature Structural Biology. 7(8):639-43. DOI: 10.1038/77929

Verdecia, M.A., Huang, H., Dutil, E., Kaiser, D.A., Hunter, T., Noel, J.P. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. (2000) Nature Structural Biology. 7(7):602-8. DOI: 10.1038/76838

Jez, J.M., Ferrer, J.L., Bowman, M.E., Dixon, R.A., Noel, J.P. Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. (2000) Biochemistry. 39(5):890-902.

Jiang, G., den Hertog, J., Su, J., Noel, J., Sap, J., Hunter, T. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha. (1999) Nature. 401(6753):606-10. DOI: 10.1038/44170

Ferrer, J.L., Jez, J.M., Bowman, M.E., Dixon, R.A., Noel, J.P. Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. (1999) Nature Structural Biology. 6(8):775-84. DOI: 10.1038/11553

Majeti, R., Bilwes, A.M., Noel, J.P., Hunter, T., Weiss, A. Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. (1998) Science. 279(5347):88-91.

Starks, C.M., Back, K., Chappell, J., Noel, J.P. Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase. (1997) Science. 277(5333):1815-20.

Noel, J.P. Turning off the Ras switch with the flick of a finger. (1997) Nature Structural Biology. 4(9):677-80.

Ranganathan, R., Lu, K.P., Hunter, T., Noel, J.P. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. (1997) Cell. 89(6):875-86.

Bilwes, A.M., den Hertog, J., Hunter, T., Noel, J.P. Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization. (1996) Nature. 382(6591):555-9. DOI: 10.1038/382555a0

Sondek, J., Lambright, D.G., Noel, J.P., Hamm, H.E., Sigler, P.B. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. (1994) Nature. 372(6503):276-9. DOI: 10.1038/372276a0

Lambright, D.G., Noel, J.P., Hamm, H.E., Sigler, P.B. Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. (1994) Nature. 369(6482):621-8. DOI: 10.1038/369621a0

Noel, J.P., Hamm, H.E., Sigler, P.B. The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. (1993) Nature. 366(6456):654-63. DOI: 10.1038/366654a0

Dupureur, C.M., Yu, B.Z., Jain, M.K., Noel, J.P., Deng, T., Li, Y., Byeon, I.J., Tsai, M.D. Phospholipase A2 engineering. Structural and functional roles of highly conserved active site residues tyrosine-52 and tyrosine-73. (1992) Biochemistry. 31(28):6402-13.

Noel, J.P., Bingman, C.A., Deng, T.L., Dupureur, C.M., Hamilton, K.J., Jiang, R.T., Kwak, J.G., Sekharudu, C., Sundaralingam, M., Tsai, M.D. Phospholipase A2 engineering. X-ray structural and functional evidence for the interaction of lysine-56 with substrates. (1991) Biochemistry. 30(51):11801-11.

Deng, T.L., Noel, J.P., Tsai, M.D. A novel expression vector for high-level synthesis and secretion of foreign proteins in Escherichia coli: overproduction of bovine pancreatic phospholipase A2. (1990) Gene. 93(2):229-34.

Noel, J.P., Tsai, M.D. Phospholipase A2 engineering: design, synthesis, and expression of a gene for bovine (pro)phospholipase A2. (1989) J. Cell. Biochem. 40(3):309-20. DOI: 10.1002/jcb.240400307

Lin, G., Noel, J., Loffredo, W., Stable, H.Z., Tsai, M.D. Use of short-chain cyclopentano-phosphatidylcholines to probe the mode of activation of phospholipase A2 from bovine pancreas and bee venom. (1988) Journal of Biological Chemistry. 263(26):13208-14.