Genomic Analysis Laboratory
Senior Staff Scientist
Genomic Analysis Laboratory
Gene expression is an intricately coordinated event. The spatio-temporal regulation of gene expression is controlled at several levels. I focus on three facets - the epigenetic, transcriptional and post-transcriptional layers of gene regulation. As a computational biologist, I analyze genomics data generated by high-throughput technologies in an effort to uncover these molecular connections, with special focus on human health and disease.
The selective chemical modification (addition of a methyl group) at the fifth carbon atom of cytosine in the DNA (commonly referred to as DNA methylation) is a key epigenetic aspect that has direct effects on gene regulation. At the Ecker lab I work towards unraveling the mechanics of how DNA methylation affects gene regulation in a variety of systems. We are part of the ENCODE Consortium Project (phase 3) where we look into the differential methylation patterns across various organs (spatial) in selected stages (temporal) of mouse embryonic development and study its effect on gene expression. These stages correspond to those at which several human developmental disorders are manifested. We have recently discovered several novel patterns of DNA methylation that assert their effects on gene expression profiles of various organs across four individuals.
Working closely with various research groups at the Salk Institute I played a major role in several research projects including, mouse schizophrenia models, human progeria syndrome, embryonic reprograming using somatic cell nuclear transfer and polar body transfer etc. I was also the lead investigator in the CIRM-funded Center for Excellence in Stem Cell Genomics where we coordinated with several stem cell researchers in California to produce multi-omic datasets. I currently lead a team of researchers to work on identifying the role of DNA methylation in gene regulation, especially in U.S. Department of Defense (DoD) funded projects – ECHO, MBA, and PHITE. I am also part of the Wu Tsai Human Performance Alliance and the MOTrPaC consortium where we study the epigenetic mechanisms during training and exercise.
For more information on my research activities (including past research) and background, please visit my website by clicking here»