Assistant Professor
Integrative Biology Laboratory
Hearst Foundation Developmental Chair
Lee, H., Yu, C.C., Boyden, E.S., Zhuang, X., Kosuri, P. Tetra-gel enables superior accuracy in combined super-resolution imaging and expansion microscopy. (2021) Scientific Reports. 11(1):16944. DOI: 10.1038/s41598-021-96258-y
Kosuri, P., Altheimer, B.D., Dai, M., Yin, P., Zhuang, X. Rotation tracking of genome-processing enzymes using DNA origami rotors. (2019) Nature. 572(7767):136-140. DOI: 10.1038/s41586-019-1397-7
Rivas-Pardo, J.A., Eckels, E.C., Popa, I., Kosuri, P., Linke, W.A., Fernández, J.M. Work Done by Titin Protein Folding Assists Muscle Contraction. (2016) Cell Reports. 14(6):1339-1347. DOI: 10.1016/j.celrep.2016.01.025
Inouye, S., Bouras, V., Shouldis, E., Johnstone, A., Silverzweig, Z., Kosuri, P. Predicting readmission of heart failure patients using automated follow-up calls. (2015) BMC Med Inform Decis Mak. 15:22. DOI: 10.1186/s12911-015-0144-8
Lee, L., Kosuri, P., Arancio, O. Picomolar amyloid-β peptides enhance spontaneous astrocyte calcium transients. (2013) J Alzheimers Dis. 38(1):49-62. DOI: 10.3233/JAD-130740
Popa, I., Kosuri, P., Alegre-Cebollada, J., Garcia-Manyes, S., Fernandez, J.M. Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy. (2013) Nature Protocols. 8(7):1261-76. DOI: 10.1038/nprot.2013.056
Kosuri, P., Alegre-Cebollada, J., Feng, J., Kaplan, A., Inglés-Prieto, A., Badilla, C.L., Stockwell, B.R., Sanchez-Ruiz, J.M., Holmgren, A., Fernández, J.M. Protein folding drives disulfide formation. (2012) Cell. 151(4):794-806. DOI: 10.1016/j.cell.2012.09.036
Alegre-Cebollada, J., Kosuri, P., Rivas-Pardo, J.A., Fernández, J.M. Direct observation of disulfide isomerization in a single protein. (2011) Nature Chemistry. 3(11):882-7. DOI: 10.1038/nchem.1155
Perez-Jimenez, R., Inglés-Prieto, A., Zhao, Z.M., Sanchez-Romero, I., Alegre-Cebollada, J., Kosuri, P., Garcia-Manyes, S., Kappock, T.J., Tanokura, M., Holmgren, A., Sanchez-Ruiz, J.M., Gaucher, E.A., Fernandez, J.M. Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. (2011) Nature Structural & Molecular Biology. 18(5):592-6. DOI: 10.1038/nsmb.2020
Alegre-Cebollada, J., Kosuri, P., Fernández, J.M. Protease power strokes force proteins to unfold. (2011) Cell. 145(3):339-40. DOI: 10.1016/j.cell.2011.04.007
Alegre-Cebollada, J., Perez-Jimenez, R., Kosuri, P., Fernandez, J.M. Single-molecule force spectroscopy approach to enzyme catalysis. (2010) Journal of Biological Chemistry. 285(25):18961-6. DOI: 10.1074/jbc.R109.011932
Fernandez, V.I., Kosuri, P., Parot, V., Fernandez, J.M. Extended Kalman filter estimates the contour length of a protein in single molecule atomic force microscopy experiments. (2009) Rev Sci Instrum. 80(11):113104. DOI: 10.1063/1.3252982
O'Connell, N.E., Grey, M.J., Tang, Y., Kosuri, P., Miloushev, V.Z., Raleigh, D.P., Palmer, A.G. Partially folded equilibrium intermediate of the villin headpiece HP67 defined by 13C relaxation dispersion. (2009) J Biomol NMR. 45(1-2):85-98. DOI: 10.1007/s10858-009-9340-0
Perez-Jimenez, R., Li, J., Kosuri, P., Sanchez-Romero, I., Wiita, A.P., Rodriguez-Larrea, D., Chueca, A., Holmgren, A., Miranda-Vizuete, A., Becker, K., Cho, S.H., Beckwith, J., Gelhaye, E., Jacquot, J.P., Gaucher, E.A., Gaucher, E., Sanchez-Ruiz, J.M., Berne, B.J., Fernandez, J.M. Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. (2009) Nature Structural & Molecular Biology. 16(8):890-6. DOI: 10.1038/nsmb.1627
Perez-Jimenez, R., Wiita, A.P., Rodriguez-Larrea, D., Kosuri, P., Gavira, J.A., Sanchez-Ruiz, J.M., Fernandez, J.M. Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis. (2008) Journal of Biological Chemistry. 283(40):27121-9. DOI: 10.1074/jbc.M803746200
Fei, J., Kosuri, P., MacDougall, D.D., Gonzalez, R.L. Coupling of ribosomal L1 stalk and tRNA dynamics during translation elongation. (2008) Molecular Cell. 30(3):348-59. DOI: 10.1016/j.molcel.2008.03.012
Postdoctoral Fellow, Harvard University
PhD, Biochemistry and Molecular Biophysics, Columbia University
MSc, Engineering Physics, KTH Royal Institute of Technology