Associate Professor
Clayton Foundation Laboratories for Peptide Biology
Pioneer Fund Developmental Chair
Jhang, J., Park, S., Liu, S., O'Keefe, D.D., Han, S. A top-down slow breathing circuit that alleviates negative affect in mice. (2024) Nature Neuroscience. DOI: 10.1038/s41593-024-01799-w
Kim, D.I., Park, S., Park, S., Ye, M., Chen, J.Y., Kang, S.J., Jhang, J., Hunker, A.C., Zweifel, L.S., Caron, K.M., Vaughan, J.M., Saghatelian, A., Palmiter, R.D., Han, S. Presynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit. (2024) Cell. DOI: 10.1016/j.cell.2024.06.035
Kang, S.J., Kim, J.H., Kim, D.I., Roberts, B.Z., Han, S. A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice. (2024) Nature Neuroscience. DOI: 10.1038/s41593-023-01504-3
Ren, X., Liu, S., Virlogeux, A., Kang, S.J., Brusch, J., Liu, Y., Dymecki, S.M., Han, S., Goulding, M., Acton, D. Identification of an essential spinoparabrachial pathway for mechanical itch. (2023) Neuron. DOI: 10.1016/j.neuron.2023.03.013
Jhang, J., Liu, S., O'Keefe, D.D., Han, S. A top-down slow breathing circuit that alleviates negative affect. (2023) bioRxiv. DOI: 10.1101/2023.02.25.529925
Kim, D.I., Park, S., Ye, M., Chen, J.Y., Jhang, J., Hunker, A.C., Zweifel, L.S., Palmiter, R.D., Han, S. Novel genetically encoded tools for imaging or silencing neuropeptide release from presynaptic terminals . (2023) bioRxiv. DOI: 10.1101/2023.01.19.524797
Kang, S.J., Liu, S., Ye, M., Kim, D.I., Pao, G.M., Copits, B.A., Roberts, B.Z., Lee, K.F., Bruchas, M.R., Han, S. A central alarm system that gates multi-sensory innate threat cues to the amygdala. (2022) Cell Reports. 40(7):111222. DOI: 10.1016/j.celrep.2022.111222
Liu, S., Han, S. Simultaneous recording of breathing and neural activity in awake behaving mice. (2022) STAR Protoc. 3(2):101412. DOI: 10.1016/j.xpro.2022.101412
Liu, S., Ye, M., Pao, G.M., Song, S.M., Jhang, J., Jiang, H., Kim, J.H., Kang, S.J., Kim, D.I., Han, S. Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions. (2021) Neuron. DOI: 10.1016/j.neuron.2021.11.029
Liu, S., Kim, D.I., Oh, T.G., Pao, G.M., Kim, J.H., Palmiter, R.D., Banghart, M.R., Lee, K.F., Evans, R.M., Han, S. Neural basis of opioid-induced respiratory depression and its rescue. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(23). DOI: 10.1073/pnas.2022134118
Campos, C.A., Bowen, A.J., Han, S., Wisse, B.E., Palmiter, R.D., Schwartz, M.W. Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus. (2017) Nature Neuroscience. 20(7):934-942. DOI: 10.1038/nn.4574
Rubinstein, M.*, Han, S.*, Tai, C., Westenbroek, R.E., Hunker, A., Scheuer, T., Catterall, W.A. Dissecting the phenotypes of Dravet syndrome by gene deletion. (2015) Brain : A Journal of Neurology. 138(Pt 8):2219-33. DOI: 10.1093/brain/awv142
Han, S., Soleiman, M.T., Soden, M.E., Zweifel, L.S., Palmiter, R.D. Elucidating an Affective Pain Circuit that Creates a Threat Memory. (2015) Cell. 162(2):363-374. DOI: 10.1016/j.cell.2015.05.057
Carter, M.E., Han, S., Palmiter, R.D. Parabrachial calcitonin gene-related peptide neurons mediate conditioned taste aversion. (2015) Journal of Neuroscience. 35(11):4582-6. DOI: 10.1523/JNEUROSCI.3729-14.2015
Han, S., Tai, C., Jones, C.J., Scheuer, T., Catterall, W.A. Enhancement of inhibitory neurotransmission by GABAA receptors having α2,3-subunits ameliorates behavioral deficits in a mouse model of autism. (2014) Neuron. 81(6):1282-1289. DOI: 10.1016/j.neuron.2014.01.016
Han, S., Tai, C., Westenbroek, R.E., Yu, F.H., Cheah, C.S., Potter, G.B., Rubenstein, J.L., Scheuer, T., de la Iglesia, H.O., Catterall, W.A. Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. (2012) Nature. 489(7416):385-90. DOI: 10.1038/nature11356
Han, S., Yu, F.H., Schwartz, M.D., Linton, J.D., Bosma, M.M., Hurley, J.B., Catterall, W.A., de la Iglesia, H.O. Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(6):E368-77. DOI: 10.1073/pnas.1115729109
Eckel-Mahan, K.L., Phan, T., Han, S., Wang, H., Chan, G.C., Scheiner, Z.S., Storm, D.R. Circadian oscillation of hippocampal MAPK activity and cAmp: implications for memory persistence. (2008) Nature Neuroscience. 11(9):1074-82.
Han, S., Kim, T.D., Ha, D.C., Kim, K.T. Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands. (2005) Journal of Biological Chemistry. 280(46):38228-34. DOI: 10.1074/jbc.M508130200
BS, Genetic Engineering, Kyungpook National University, Korea
MS, Neuroscience, Pohang University of Science and Technology, Korea
PhD, Neurobiology & Behavior, University of Washington, Seattle