Distinguished Professor Emerita
Thomas, S.T., Louie, G.V., Lubin, J.W., Lundblad, V., Noel, J.P. Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase. (2019) ACS Chemical Biology. 14(8):1767-1779. DOI: 10.1021/acschembio.9b00322
Paul Solomon Devakumar, L.J., Gaubitz, C., Lundblad, V., Kelch, B.A., Kubota, T. Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex. (2019) Nucleic Acids Research. 47(13):6826-6841. DOI: 10.1093/nar/gkz441
Glustrom, L.W., Lyon, K.R., Paschini, M., Reyes, C.M., Parsonnet, N.V., Toro, T.B., Lundblad, V., Wuttke, D.S. Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function. (2018) Proceedings of the National Academy of Sciences of the United States of America. 115(41):10315-10320. DOI: 10.1073/pnas.1722147115
Lubin, J.W., Tucey, T.M., Lundblad, V. Using Separation-of-Function Mutagenesis To Define the Full Spectrum of Activities Performed by the Est1 Telomerase Subunit in Vivo. (2017) Genetics. 208(1):97-110. DOI: 10.1534/genetics.117.300145
Tucey, T.M., Lundblad, V. Regulated assembly and disassembly of the yeast telomerase quaternary complex. (2014) Genes & Development. 28(19):2077-89. DOI: 10.1101/gad.246256.114
Rao, T., Lubin, J.W., Armstrong, G.S., Tucey, T.M., Lundblad, V., Wuttke, D.S. Structure of Est3 reveals a bimodal surface with differential roles in telomere replication. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(1):214-8. DOI: 10.1073/pnas.1316453111
Ballew, B.J., Lundblad, V. Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast. (2013) Aging Cell. 12(4):719-27. DOI: 10.1111/acel.12099
Lubin, J.W., Rao, T., Mandell, E.K., Wuttke, D.S., Lundblad, V. Dissecting protein function: an efficient protocol for identifying separation-of-function mutations that encode structurally stable proteins. (2013) Genetics. 193(3):715-25. DOI: 10.1534/genetics.112.147801
Tucey, T.M., Lundblad, V. A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle. (2013) Biochemistry. 52(7):1131-3. DOI: 10.1021/bi3015218
Lubin, J.W., Tucey, T.M., Lundblad, V. The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements. (2012) RNA. 18(9):1597-604. DOI: 10.1261/rna.034447.112
Lundblad, V. Telomere end processing: unexpected complexity at the end game. (2012) Genes & Development. 26(11):1123-7. DOI: 10.1101/gad.195339.112
Paschini, M., Toro, T.B., Lubin, J.W., Braunstein-Ballew, B., Morris, D.K., Lundblad, V. A naturally thermolabile activity compromises genetic analysis of telomere function in Saccharomyces cerevisiae. (2012) Genetics. 191(1):79-93. DOI: 10.1534/genetics.111.137869
Mandell, E.K., Gelinas, A.D., Wuttke, D.S., Lundblad, V. Sequence-specific binding to telomeric DNA is not a conserved property of the Cdc13 DNA binding domain. (2011) Biochemistry. 50(29):6289-91. DOI: 10.1021/bi2005448
Gao, H., Toro, T.B., Paschini, M., Braunstein-Ballew, B., Cervantes, R.B., Lundblad, V. Telomerase recruitment in Saccharomyces cerevisiae is not dependent on Tel1-mediated phosphorylation of Cdc13. (2010) Genetics. 186(4):1147-59. DOI: 10.1534/genetics.110.122044
Paschini, M., Mandell, E.K., Lundblad, V. Structure prediction-driven genetics in Saccharomyces cerevisiae identifies an interface between the t-RPA proteins Stn1 and Ten1. (2010) Genetics. 185(1):11-21. DOI: 10.1534/genetics.109.111922
Lee, J., Mandell, E.K., Rao, T., Wuttke, D.S., Lundblad, V. Investigating the role of the Est3 protein in yeast telomere replication. (2010) Nucleic Acids Research. 38(7):2279-90. DOI: 10.1093/nar/gkp1173
Gelinas, A.D., Paschini, M., Reyes, F.E., Héroux, A., Batey, R.T., Lundblad, V., Wuttke, D.S. Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain. (2009) Proceedings of the National Academy of Sciences of the United States of America. 106(46):19298-303. DOI: 10.1073/pnas.0909203106
Lee, J., Mandell, E.K., Tucey, T.M., Morris, D.K., Lundblad, V. The Est3 protein associates with yeast telomerase through an OB-fold domain. (2008) Nature Structural & Molecular Biology. 15(9):990-7.
Effros, R.B., Austad, S., Blau, H., Chesselet, M.F., Ingram, D., Johnson, T.E., Kaeberlein, M., Lundblad, V., McCarter, R., McElhaney, J., Saag, M. The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America. (2008) J. Gerontol. A Biol. Sci. Med. Sci. 63(4):331-7.
Gao, H., Cervantes, R.B., Mandell, E.K., Otero, J.H., Lundblad, V. RPA-like proteins mediate yeast telomere function. (2007) Nature Structural & Molecular Biology. 14(3):208-14. DOI: 10.1038/nsmb1205
Lundblad, V. Telomeres in the '80s: a few recollections. (2006) Nature Structural & Molecular Biology. 13(12):1036-8. DOI: 10.1038/nsmb1206-1036
Bertuch, A.A., Lundblad, V. The maintenance and masking of chromosome termini. (2006) Current Opinion in Cell Biology. 18(3):247-53. DOI: 10.1016/j.ceb.2006.04.005
Baumgartner, B.L., Lundblad, V. Telomere identity crisis. (2005) Genes & Development. 19(21):2522-5. DOI: 10.1101/gad.1373205
Chappell, A.S., Lundblad, V. Structural elements required for association of the Saccharomyces cerevisiae telomerase RNA with the Est2 reverse transcriptase. (2004) Molecular and Cellular Biology. 24(17):7720-36. DOI: 10.1128/MCB.24.17.7720-7736.2004
Bertuch, A.A., Lundblad, V. EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae. (2004) Genetics. 166(4):1651-9.
Bertuch, A.A., Lundblad, V. The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini. (2003) Molecular and Cellular Biology. 23(22):8202-15.
Bertuch, A.A., Lundblad, V. Which end: dissecting Ku's function at telomeres and double-strand breaks. (2003) Genes & Development. 17(19):2347-50. DOI: 10.1101/gad.1146603
Theobald, D.L., Cervantes, R.B., Lundblad, V., Wuttke, D.S. Homology among telomeric end-protection proteins. (2003) Structure. 11(9):1049-50.
Lowell, J.E., Roughton, A.I., Lundblad, V., Pillus, L. Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiae. (2003) Genetics. 164(3):909-21.
Lundblad, V. Telomeres: taking the measure. (2003) Nature. 423(6943):926-7. DOI: 10.1038/423926a
Bertuch, A.A., Buckley, K., Lundblad, V. The way to the end matters--the role of telomerase in tumor progression. (2003) Cell Cycle. 2(1):36-8. DOI: 10.4161/cc.2.1.278
Lundblad, V. Telomere replication: an Est fest. (2003) Current Biology. 13(11):R439-41.
Evans, S.K., Lundblad, V. The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance. (2002) Genetics. 162(3):1101-15.
Cervantes, R.B., Lundblad, V. Mechanisms of chromosome-end protection. (2002) Current Opinion in Cell Biology. 14(3):351-6.
Mitton-Fry, R.M., Anderson, E.M., Hughes, T.R., Lundblad, V., Wuttke, D.S. Conserved structure for single-stranded telomeric DNA recognition. (2002) Science. 296(5565):145-7. DOI: 10.1126/science.1068799
Lundblad, V. Telomere maintenance without telomerase. (2002) Oncogene. 21(4):522-31. DOI: 10.1038/sj.onc.1205079
Lundblad, V. Genome instability: McClintock revisited. (2001) Current Biology. 11(23):R957-60.
Rizki, A., Lundblad, V. Defects in mismatch repair promote telomerase-independent proliferation. (2001) Nature. 411(6838):713-6. DOI: 10.1038/35079641
Hanna, J.S., Kroll, E.S., Lundblad, V., Spencer, F.A. Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion. (2001) Molecular and Cellular Biology. 21(9):3144-58. DOI: 10.1128/MCB.21.9.3144-3158.2001
Lundblad, V., Zhou, H. Manipulation of plasmids from yeast cells. (2001) Current Protocols in Molecular Biology. Chapter 13:Unit13.9. DOI: 10.1002/0471142727.mb1309s39
Reynolds, A., Lundblad, V., Dorris, D., Keaveney, M. Yeast vectors and assays for expression of cloned genes. (2001) Current Protocols in Molecular Biology. Chapter 13:Unit13.6. DOI: 10.1002/0471142727.mb1306s39
Treco, D.A., Lundblad, V. Preparation of yeast media. (2001) Current Protocols in Molecular Biology. Chapter 13:Unit13.1. DOI: 10.1002/0471142727.mb1301s23
Lundblad, V., Hartzog, G., Moqtaderi, Z. Manipulation of cloned yeast DNA. (2001) Current Protocols in Molecular Biology. Chapter 13:Unit13.10. DOI: 10.1002/0471142727.mb1310s39
Lundblad, V. Yeast cloning vectors and genes. (2001) Current Protocols in Molecular Biology. Chapter 13:Unit13.4. DOI: 10.1002/0471142727.mb1304s21
Becker, D.M., Lundblad, V. Introduction of DNA into yeast cells. (2001) Current Protocols in Molecular Biology. Chapter 13:Unit13.7. DOI: 10.1002/0471142727.mb1307s27
Lundblad, V. Cloning yeast genes by complementation. (2001) Current Protocols in Molecular Biology. Chapter 13:Unit13.8. DOI: 10.1002/0471142727.mb1308s05
Treco, D.A., Reynolds, A., Lundblad, V. Growth and manipulation of yeast. (2001) Current Protocols in Protein Science. Appendix 4:Appendix 4L. DOI: 10.1002/0471140864.psa04ls14
Pennock, E., Buckley, K., Lundblad, V. Cdc13 delivers separate complexes to the telomere for end protection and replication. (2001) Cell. 104(3):387-96. DOI: 10.1016/s0092-8674(01)00226-4
Chandra, A., Hughes, T.R., Nugent, C.I., Lundblad, V. Cdc13 both positively and negatively regulates telomere replication. (2001) Genes & Development. 15(4):404-14. DOI: 10.1101/gad.861001
Evans, S.K., Lundblad, V. Positive and negative regulation of telomerase access to the telomere. (2000) Journal of Cell Science. 113 Pt 19:3357-64.
Hughes, T.R., Evans, S.K., Weilbaecher, R.G., Lundblad, V. The Est3 protein is a subunit of yeast telomerase. (2000) Current Biology. 10(13):809-12.
Lundblad, V. DNA ends: maintenance of chromosome termini versus repair of double strand breaks. (2000) Mutation Research. 451(1-2):227-40.
Lundblad, V. Molecular biology. Telomeres keep on rappin'. (2000) Science. 288(5474):2141-2.
Hughes, T.R., Weilbaecher, R.G., Walterscheid, M., Lundblad, V. Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein. (2000) Proceedings of the National Academy of Sciences of the United States of America. 97(12):6457-62.
Lundblad, V. Telomeres: a tale of ends. (2000) Nature. 403(6766):149, 151. DOI: 10.1038/35003085
Weilbaecher, R.G., Lundblad, V. Assembly and regulation of telomerase. (1999) Current Opinion in Chemical Biology. 3(5):573-7.
Zumstein, L.A., Lundblad, V. Telomeres: has cancer's Achilles' heel been exposed? (1999) Nature Medicine. 5(10):1129-30. DOI: 10.1038/13451
Evans, S.K., Lundblad, V. Est1 and Cdc13 as comediators of telomerase access. (1999) Science. 286(5437):117-20.
Evans, S.K., Bertuch, A.A., Lundblad, V. Telomeres and telomerase: at the end, it all comes together. (1999) Trends in Cell Biology. 9(8):329-31.
Weinert, T., Lundblad, V. Forever hopeful relations: chromatin, telomeres and checkpoints. (1999) Nature Genetics. 21(2):151-2. DOI: 10.1038/5930
Evans, S.K., Sistrunk, M.L., Nugent, C.I., Lundblad, V. Telomerase, Ku, and telomeric silencing in Saccharomyces cerevisiae. (1998) Chromosoma. 107(6-7):352-8.
Bertuch, A., Lundblad, V. Telomeres and double-strand breaks: trying to make ends meet. (1998) Trends in Cell Biology. 8(9):339-42.
Lundblad, V. Telomerase catalysis: a phylogenetically conserved reverse transcriptase. (1998) Proceedings of the National Academy of Sciences of the United States of America. 95(15):8415-6.
Nugent, C.I., Bosco, G., Ross, L.O., Evans, S.K., Salinger, A.P., Moore, J.K., Haber, J.E., Lundblad, V. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. (1998) Current Biology. 8(11):657-60.
Nugent, C.I., Lundblad, V. The telomerase reverse transcriptase: components and regulation. (1998) Genes & Development. 12(8):1073-85.
Morris, D.K., Lundblad, V. Programmed translational frameshifting in a gene required for yeast telomere replication. (1997) Current Biology. 7(12):969-76.
Lundblad, V. The end replication problem: more than one solution. (1997) Nature Medicine. 3(11):1198-9.
Lingner, J., Cech, T.R., Hughes, T.R., Lundblad, V. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94(21):11190-5.
Hughes, T.R., Morris, D.K., Salinger, A., Walcott, N., Nugent, C.I., Lundblad, V. The role of the EST genes in yeast telomere replication. (1997) Ciba Foundation Symposium. 211:41-7; discussion 47-52, 71-5.
Lingner, J., Hughes, T.R., Shevchenko, A., Mann, M., Lundblad, V., Cech, T.R. Reverse transcriptase motifs in the catalytic subunit of telomerase. (1997) Science. 276(5312):561-7.
Lendvay, T.S., Morris, D.K., Sah, J., Balasubramanian, B., Lundblad, V. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. (1996) Genetics. 144(4):1399-412.
Virta-Pearlman, V., Morris, D.K., Lundblad, V. Est1 has the properties of a single-stranded telomere end-binding protein. (1996) Genes & Development. 10(24):3094-104. DOI: 10.1101/gad.10.24.3094
Lundblad, V., Wright, W.E. Telomeres and telomerase: a simple picture becomes complex. (1996) Cell. 87(3):369-75. DOI: 10.1016/s0092-8674(00)81358-6
Nugent, C.I., Hughes, T.R., Lue, N.F., Lundblad, V. Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. (1996) Science. 274(5285):249-52.
Lundblad, V., Blackburn, E.H. An alternative pathway for yeast telomere maintenance rescues est1- senescence. (1993) Cell. 73(2):347-60.
Lundblad, V., Blackburn, E.H. RNA-dependent polymerase motifs in EST1: tentative identification of a protein component of an essential yeast telomerase. (1990) Cell. 60(4):529-30.
Lundblad, V., Szostak, J.W. A mutant with a defect in telomere elongation leads to senescence in yeast. (1989) Cell. 57(4):633-43.
Lundblad, V., Kleckner, N. Mismatch repair mutations of Escherichia coli K12 enhance transposon excision. (1985) Genetics. 109(1):3-19.
Lundblad, V., Taylor, A.F., Smith, G.R., Kleckner, N. Unusual alleles of recB and recC stimulate excision of inverted repeat transposons Tn10 and Tn5. (1984) Proceedings of the National Academy of Sciences of the United States of America. 81(3):824-8.
Lundblad, V., Kleckner, N. Mutants of Escherichia coli K12 which affect excision of transposon Tn10. (1982) Basic Life Sci. 20:245-58.
Foster, T.J., Lundblad, V., Hanley-Way, S., Halling, S.M., Kleckner, N. Three Tn10-associated excision events: relationship to transposition and role of direct and inverted repeats. (1981) Cell. 23(1):215-27.
Kleckner, N., Foster, T.J., Davis, M.A., Hanley-Way, S., Halling, S.M., Lundblad, V., Takeshita, K. Genetic organization of Tn10 and analysis of Tn10-associated excision events. (1981) Cold Spring Harbor Symposia on Quantitative Biology. 45 Pt 1:225-38.
Wiche, G., Lundblad, V.J., Cole, R.D. Competence of soluble cell extracts as microtubule assembly systems. Comparison of simian virus 40 transformed and nontransformed mouse 3T3 fibroblasts. (1977) Journal of Biological Chemistry. 252(2):794-6.